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Nalbun Injection 1ml
Nalbun Injection is indicated for the relief of moderate to severe pain. It is particularly used in:
- Myocardial infarction (MI)
- Preoperative and postoperative analgesia
- Balanced anesthesia supplementation
- Obstetrical analgesia during labor and delivery
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✅ Description:
Nalbuphine Hydrochloride (Nalbun) is a synthetic opioid analgesic that binds to mu, kappa, and delta receptors, excluding sigma receptors. Its analgesic potency is equivalent to morphine on a milligram basis and is 10 times more potent than pentazocine, but with lower side effects and less abuse potential. The onset of action is 2 to 3 minutes after intravenous administration and less than 15 minutes following intramuscular injection. The plasma half-life is 5 hours, and the duration of analgesic activity ranges from 3 to 6 hours.
Safety Advices
Alcohol
UNSAFE
You are advised not to take alcohol with Nalbuphine as it might cause increased sedation and respiratory depression.
Pregnancy
CONSULT YOUR DOCTOR
Nalbuphine is not recommended for use during pregnancy unless absolutely indicated. Please consult your doctor if you have any concerns.
Breastfeeding
CONSULT YOUR DOCTOR
Nalbuphine should be used with caution during breastfeeding. Please consult your doctor if you have any concerns.
Driving
UNSAFE
Nalbuphine may cause dizziness and drowsiness, which may affect your ability to drive.
Kidney
CAUTION
Exercise caution before using Nalbuphine in case of established liver disease. Please consult your doctor to address any concerns.
Liver
CAUTION
Exercise caution before using Nalbuphine in case of kidney problems. Please consult your doctor to address any concerns.
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✔️ Uses of Nalbun Injection
Pain Relief
✔️ How does Nalbun Injection work?
Nalbun blocks pain signals, so the brain doesn't perceive the severity of pain, hence increasing the body's threshold for pain.
✔️ Side Effects of Nalbun Injection
Commonly well tolerated but may include:
- Sedation
- Sweating
- Nausea
- Vomiting
- Dizziness
- Vertigo
- Dry mouth
- Headache
- Respiratory depression
- Dyspnea
- Asthma
✔️ Quick Suggestions:
- Use Nalbuphine as instructed by your doctor. Never take in greater amounts or more often than prescribed.
- It causes sleepiness or drowsiness. If this happens to you, do not drive or use machinery.
- Avoid consuming alcohol when taking the Nalbuphine, as it may cause excessive sleepiness or drowsiness.
- Inform your doctor if you have ever been diagnosed with kidney or liver problems.
- Store opioid pain relievers in a safe place and out of reach of others.
✔️ Indication of Nalbun Injection
Nalbuphine is used for moderate to severe pain.
✔️ Pharmacology
Nalbuphine Hydrochloride is a synthetic, potent analgesic with effects comparable to morphine. It functions primarily as a kappa agonist and partial mu antagonist. Key pharmacological properties include:
- Receptor Binding: Binds to mu, kappa, and delta receptors, but not sigma receptors.
- Onset of Action: 2 to 3 minutes after intravenous administration; less than 15 minutes after subcutaneous or intramuscular injection.
- Plasma Half-Life: Approximately 5 hours.
- Duration of Analgesic Activity: Ranges from 3 to 6 hours.
✔️ Dosage & Administration of Nalbun Injection
Adults:
Moderate to Severe Pain:
- 10-20 mg for a 70 kg patient, via intramuscular or intravenous injection.
- Adjust dosage based on pain severity, patient’s physical status, and other medications.
- Repeat every 3 to 6 hours as necessary.
Preoperative Anesthesia:
- 0.1-0.2 mg/kg via intravenous or intramuscular injection.
Obstetrical Analgesia (Labor & Delivery):
- 0.3-1 mg/kg via intravenous injection over 10-15 minutes.
- Maintenance doses of 0.25-0.5 mg/kg as needed.
Intraoperative Analgesia:
- 0.25-0.5 mg/kg via intravenous injection at 30-minute intervals.
Myocardial Infarction:
- 10-20 mg via slow intravenous injection.
- Repeat after 30 minutes if necessary.
Children (18 months to 15 years old):
- Analgesia:
- 0.2 mg/kg body weight, preferably via intravenous or intramuscular injection.
- Maintenance doses every 4 to 6 hours, as determined by a physician.
✔️ Interaction
- No hazardous interactions were identified specifically for Nalbun.
- Anticipated interactions include additive effects when combined with:
- Narcotic analgesics
- General anesthesia
- Phenothiazines
- Tranquilizers
- Sedatives
- Hypnotics
- CNS depressants (including alcohol)
✔️ Contraindications
Known hypersensitivity to Nalbuphine Hydrochloride.
✔️ Pregnancy & Lactation
- Pregnancy Category B: High and rapid placental transfer. Use only if clearly needed.
- Lactation: Limited data suggest minimal excretion in maternal milk with no significant clinical effect. Exercise caution when administering to nursing women.
✔️ Precautions & Warnings
Use with caution in:
- Impaired respiration
- Impaired renal or hepatic function
- Biliary tract surgery
- Myocardial infarction
- Hypotension
✔️ Storage Conditions:
- Store below 30°C, protected from light.
- Keep out of reach of children.
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