Naburel 750 Tablet

✔️ Side Effects

Gastrointestinal

• Diarrhea
• Dyspepsia
• Abdominal pain
• Constipation
• Flatulence
• Nausea
• Gastritis
• Stomatitis
• Vomiting
• Dry mouth
• Positive stool guaiac

Central Nervous System

• Dizziness
• Headache
• Fatigue
• Increased sweating
• Insomnia
• Nervousness
• Somnolence

Dermatologic

• Pruritus
• Skin rash

Special Senses

• Tinnitus

Miscellaneous

• Oedema

NSAIDs can also cause serious gastrointestinal, cardiovascular, renal, hepatic, and hypersensitivity reactions. Seek medical attention if severe abdominal pain, gastrointestinal bleeding, breathing difficulty, facial swelling, severe skin reactions, or significant reduction in urine output occurs.

✔️ Nabumetone is contraindicated in patients with:

• Known hypersensitivity to nabumetone or any component of the formulation
• A history of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
• Known serious NSAID-related hypersensitivity reactions

Nabumetone is also contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Severe, potentially fatal anaphylactic or anaphylactoid reactions have been reported with NSAIDs, particularly in susceptible patients.

✔️ Interaction

NSAIDs may reduce the antihypertensive effect of ACE inhibitors. This interaction should be considered when nabumetone is administered concomitantly with an ACE inhibitor.

NSAIDs may also interact with several other medicines. Patients should inform their healthcare provider about all prescription medicines, over-the-counter medicines, and supplements they are taking.

✔️ Pregnancy & Lactation

Pregnancy 

Nabumetone should be used during pregnancy only when clearly needed and after careful medical assessment.

Because prostaglandin synthesis inhibitors may affect the fetal cardiovascular system and may contribute to premature closure of the ductus arteriosus, nabumetone should generally be avoided during the third trimester of pregnancy.

Lactation

Nabumetone is not recommended during breastfeeding unless specifically advised by a healthcare professional, due to the potential for adverse effects in the nursing infant.

✔️ Precautions & Warnings

NSAIDs, including nabumetone, may cause renal toxicity, particularly during prolonged treatment or in patients with risk factors for reduced renal blood flow.

Patients at increased risk include those with:

• Pre-existing renal impairment
• Heart failure
• Liver dysfunction
• Dehydration or reduced circulating blood volume
• Concomitant diuretic therapy
• Older age

In susceptible patients, inhibition of renal prostaglandin synthesis may reduce renal blood flow and precipitate renal dysfunction.

Renal function should be monitored when clinically appropriate, particularly during prolonged treatment or in high-risk patients.

NSAIDs should be used at the lowest effective dose for the shortest appropriate duration to reduce the risk of adverse effects.

✔️ Storage Conditions

• Store in a cool and dry place.
• Protect from light and moisture.
• Keep the medicine out of reach of children.
• Store according to the specific product label.