Injection, Generic Name: Diclofenac Sodium, Manufacturer: Incepta Pharmaceuticals Ltd.
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Indications of Intafenac 75mg
The injection includes Diclofenac Sodium, which is used to treat various types of pain and inflammation in a variety of diseases, including:
Rheumatoid arthritis, osteoarthritis, juvenile chronic arthritis, ankylosing spondylitis, and acute gout are all examples of arthritic diseases.
Periarthritis (e.g., frozen shoulder), tendinitis, tenosynovitis, and bursitis are examples of acute musculoskeletal diseases.
Other painful disorders caused by trauma include fractures, low back pain, sprains, strains, dislocations, pain and inflammation control in orthopedic, dentistry, and other minor operations, postoperative pain, pain from renal colic, and so on.
Lidocaine, which works as a local anesthetic, is also included in the injection. As a result, if the Diclofenac Sodium + Lidocaine Hydrochloride injection is used in the aforementioned indications, the likelihood of discomfort at the injection site, which is most probable following intramuscular administration, is reduced.
Pharmacology
Diclofenac sodium is a very effective nonsteroidal anti-inflammatory medication (NSAID) having analgesic and antipyretic effects. It also possesses uricosuric properties. Diclofenac's effect appears to be related to the suppression of prostaglandin production. Diclofenac may prevent prostaglandin production by inhibiting cyclooxygenase, an enzyme that catalyzes the generation of prostaglandin precursors from arachidonic acid. Within half an hour of injection, the plasma concentration reaches its peak.
The most often used local anesthetic is lidocaine. It has a faster onset of action and is more stable than most other local anesthetics. It's a great surface anesthetic. Lidocaine, like other local anesthetics, slows depolarization and hence affects nerve impulse production and conduction. The onset of anesthesia with Lidocaine Hydrochloride is faster, with a duration of 1-2 hours.
Dosage & Administration
Interaction of Intafenac 75mg Injection
Diclofenac may raise the plasma concentrations of lithium and digoxin.
Anticoagulants: There have been rare reports of an increased risk of bleeding when Diclofenac is taken with anticoagulant treatment, however, clinical studies do not appear to suggest any effect on anticoagulant action.
Antidiabetic medications: Clinical investigations have demonstrated that Diclofenac can be used concurrently with oral antidiabetic medicines without affecting their clinical efficacy.
Cyclosporin: Nephrotoxicity has been documented in people using Cyclosporin and Diclofenac at the same time.
Methotrexate: Serious toxicity has been observed when methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) are administered within 24 hours of each other.
Quinolone antimicrobials: Quinolones and NSAIDs may interact, causing convulsions. As a result, while contemplating NSAID and quinolone concurrent treatment, take care.
Co-administration of Diclofenac with other systemic NSAIDs and steroids may increase the incidence of adverse effects. Aspirin lowers plasma levels of both, however, no clinical relevance is recognized.
Diuretics: A variety of NSAIDs have been shown to impair the action of diuretics. Concurrent use of potassium-sparing diuretics may result in elevated blood potassium levels. As a result, serum potassium levels should be checked.
Contraindications
It is not recommended for people who are hypersensitive to Diclofenac. Diclofenac is also contraindicated in patients with active or suspected peptic ulcers or gastrointestinal bleeding, or in individuals whose episodes of asthma, urticaria, or acute rhinitis are initiated by Aspirin or other NSAIDs with prostaglandin synthetase inhibitory action. Because of the inclusion of Lidocaine, this injection is also contraindicated for individuals who are hypersensitive to amide-type local anesthetics, albeit this is quite unusual. In the absence of an artificial pacemaker in individuals with Adams-Stokes syndrome or severe degrees of SA, AV, or intraventricular heart block, This injection is also contraindicated for individuals who are allergic to any of the excipients included in the formulation (Sodium Metabisulphite, Disodium Edetate, Benzyl Alcohol, Sodium Hydroxide, Propylene Glycol).
Side Effects of Intafenac Plus
Diclofenac Sodium with Lidocaine injectable side effects are often minor and transitory. If significant adverse effects develop, the injection should be stopped. It is possible to have gastrointestinal pain, nausea, diarrhea, and, on rare occasions, bleeding. Injection site dysfunction can develop in extremely uncommon cases. Abscesses and local necrosis may occur in rare situations. The adverse effects of Lidocaine primarily affect the CNS, are typical of short duration, and are dosage dependent. Drowsiness, dizziness, disorientation, confusion, lightheadedness, and other CNS responses may occur.
Pregnancy & Lactation
Pregnancy Use: It should not be prescribed during pregnancy unless there are compelling reasons to do so. It is best to take the lowest effective dosage. These medications are not advised to be taken during the third trimester of pregnancy.
Use during lactation: Although very tiny amounts of Diclofenac may be found in breast milk, no adverse effects on the newborn are predicted.
Precautions & Warnings
Renal: Patients with severe hepatic, cardiac, or renal insufficiency, as well as the elderly, should be closely monitored since NSAIDs might cause the renal function to deteriorate. The smallest effective dose should be administered, and renal function should be closely monitored.
Diclofenac should be discontinued if abnormal liver function tests persist or worsen, clinical signs or symptoms associated with liver disease emerge, or if additional manifestations (eosinophilia, rash) arise. As a preventive step, all patients undergoing long-term NSAID therapy should be observed (e.g., renal, hepatic function, and blood counts).
Storage Conditions
Store in a dry location at a temperature not exceeding 30° C. Light is kept out.
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