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Skycillin is indicated for the treatment of infections caused by susceptible strains of the following organisms:
Bacteriological studies to determine the causative organisms and their sensitivity to ampicillin should be performed. Therapy may be instituted before the results of susceptibility testing.
Bacterial infections.
Ampicillin is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.
Nausea, vomiting, diarrhea, erythematous maculopapular rashes, sore mouth, black/hairy tongue, rash, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, angioedema, fever, joint pains, serum sickness-like symptoms, hemolytic anemia, thrombocytopenia, leukopenia, neutropenia, coagulation disorders, prolonged bleeding time and prothrombin time, CNS toxicity (e.g., convulsions), paraesthesia, nephropathy, interstitial nephritis, hepatitis, cholestatic jaundice, moderate and transient increase in transaminases, anaphylaxis, Clostridium difficile-associated diarrhea (CDAD).
Ampicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs), which in turn inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Bacteria eventually lyse due to the ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
Intra-articular:
Intraperitoneal:
Intrapleural:
Intravenous:
Oral:
Parenteral:
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