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Saga 200mg Tablet 5Pcs
Type: Tab. Generic Name:Sparfloxacin INN 200mg/tablet. Manufacturer/Distributor: Square
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✅ Description:
Indications
The antibiotic sparfloxacin is used to treat the following infections caused by susceptible microorganisms:
Sinusitis, acute exacerbation of chronic bronchitis, and community and hospital-acquired pneumonia are examples of upper and lower respiratory tract infections.
Gonococcal and non-gonococcal urethritis, chancroid, and other sexually transmitted illnesses are all examples of urinary tract infections.
Infections affecting the skin and soft tissues.
Use as a prophylactic in a variety of urological and ophthalmology procedures.
Pharmacology
This is a sterile ophthalmic suspension of Loteprednol Etabonate (corticosteroid) and Gatifloxacin (antibiotic) for use in the eyes.
Loteprednol is supposed to work by inducing lipocortins, which are phospholipase A2 inhibitory proteins. These proteins are thought to regulate the manufacture of powerful inflammatory mediators like prostaglandins and leukotrienes by preventing the release of their common precursor arachidonic acid. Phospholipase A2 releases arachidonic acid from membrane phospholipids.
Gatifloxacin inhibits DNA gyrase and topoisomerase IV, which is why it has antibacterial properties. DNA gyrase is a type of enzyme that breaks down DNA.
Dosage & Administration
In patients with normal renal function the recommended daily dose is two tablets of Sparfloxacin 200 mg on first day as a loading dose, thereafter take one tablet of Sparfloxacin 200 mg every 24 hours for a total of 10 days of therapy.
The recommended daily dose of Sparfloxacin in patients with renal impairment (Creatinine clearance < 30 ml/min) is two tablets of 200 mg taken on the first day as a loading dose. Thereafter, should be taken one tablet of 200 mg every 48 hours for total of 9 days of therapy.
Interaction
There is an increased risk of arrhythmia when Quinidine, Sotalol, Erythromycin, Astemizole, Terfenadine, and vinca alkaloids are used together. Magnesium, aluminum, and calcium salts, oxides, and hydroxides reduce Sparfloxacin absorption.
Contraindications
Sparfloxacin is contraindicated in people with a history of hypersensitivity, in the achilles tendon after a fluoroquinolone treatment, and during pregnancy and breastfeeding. Sparfloxacin is not recommended for patients who have a known QTc prolongation or who are taking drugs that cause an increase in the QTc interval and/or torsade depointes.
Side Effects
Most of the adverse events were mild to moderate in severity and transient in nature. The most frequently reported events among the Sparfloxacin treated patients with the recommended dosage are: diarrhea, nausea, headache, dyspepsia, dizziness, insomnia, abdominal pain and QTc interval prolongation.
Pregnancy & Lactation
There are no adequate and well controlled studies in pregnant women. Sparfloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Precautions & Warnings
It should be used with caution in patients with renal disease, stomach ulcers, or who are taking NSAIDs at the same time. Dosage modification is advised in third-degree renal failure (creatinine clearance 30 ml/min): 400 mg on the first day, 200 mg on the second and third days, and then 200 mg every 48 hours. Sparfloxacin should be stopped at the first sign of tendon soreness because fluoroquinolones have been linked to tendon rupture. During therapy, avoid being exposed to UV radiation
Storage Conditions
Store at temperature below 30° C.
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