Panovir 400mg+100mg | 1 Strip

✔️ Side Effects

Common Adverse Reactions:

Fatigue, headache, nausea, insomnia, diarrhea, anemia, itching, muscle cramps, cough, and breathlessness

Less Common but Notable:

Reductions in hemoglobin, lymphocyte, neutrophil, and platelet counts.

Bradycardia (notably with amiodarone coadministration)

✔️ Dosage & Administration

Pre-Treatment Testing:

Screen all patients for current or past Hepatitis B infection (HBsAg and anti-HBc) before starting treatment.

Adults:

Usual dose: One tablet (Sofosbuvir 400 mg + Velpatasvir 100 mg) taken once daily, with or without food.

In decompensated cirrhosis, add ribavirin:

<75 kg: 1,000 mg/day (divided BID)

≥75 kg: 1,200 mg/day (divided BID)

Pediatrics (3 years and older):

Dose is based on body weight; refer to specific pediatric dosing tables.

✔️ Overdose Management

No antidote. If overdose occurs:

• Monitor for toxicity
• Provide supportive care
• Hemodialysis may help remove Sofosbuvir metabolite (GS-331007), but not Velpatasvir due to high protein binding.

✔️ Drug Interactions

Drugs That Decrease Efficacy:

CYP3A4/P-gp inducers (e.g., Rifampin, St. John’s Wort, Carbamazepine) can lower plasma levels of both components—avoid concurrent use.

Sofosbuvir/Velpatasvir as Inhibitors:

Velpatasvir inhibits P-gp, BCRP, and OATP transporters. Caution is needed when coadministering drugs that depend on these transporters, as it may increase their plasma concentration.

Serious Interaction:

Coadministration with Amiodarone may lead to life-threatening symptomatic bradycardia. Avoid use if possible. If necessary, inpatient cardiac monitoring is advised during the initial 48 hours and outpatient heart rate monitoring for 2 weeks.

✔️ Contraindications:

Any contraindications to Ribavirin also apply when used in combination. Refer to ribavirin’s product details.

✔️ Use in Pregnancy & Lactation

Pregnancy: If coadministered with ribavirin, contraindicated in pregnant women and in men with pregnant partners due to teratogenic risks.

Breastfeeding: Unknown if drug components are excreted in human milk; caution advised.

Reproductive Potential: When combined with ribavirin, pregnancy testing and contraception are mandatory. Refer to ribavirin guidelines.

✔️ Storage Conditions

Store in a cool, dry place (preferably below 30°C), away from light and moisture.

Keep out of reach of children