Bacitracin Zinc 250 IU + Neomycin Sulphate 5mg/gm Ointment is used in the treatment of bacterial skin infections.
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Bacterial skin infections
Bacitracin: Inhibits bacterial cell wall synthesis and is effective against many gram-positive bacteria (e.g., staphylococci, streptococci, corynebacteria, Clostridia) and some gram-negative species (e.g., Neisseria, Haemophilus influenzae). Bacitracin is often found in combination with other agents in topical preparations for its broad-spectrum antibacterial activity.
Neomycin: An aminoglycoside similar to gentamicin, it binds to the 30S subunits of bacterial ribosomes, inhibiting protein synthesis and disrupting DNA synthesis. Neomycin is active against many gram-negative aerobes and some strains of staphylococci.
Generally well tolerated. Rare cases of allergic reactions may occur.
This combination is indicated for the treatment of topical bacterial infections. It is particularly effective for:
It may also be useful as an adjunct treatment for pyodermas, such as impetigo, during specific systemic antibiotic therapy.
Neomycin, an aminoglycoside with antimicrobial properties akin to gentamicin, functions by binding to the 30S subunits of the bacterial ribosome, thereby impeding protein synthesis and disrupting DNA synthesis. It exhibits activity against numerous gram-negative aerobes and certain strains of staphylococci. Conversely, Bacitracin hinders bacterial cell wall synthesis and demonstrates efficacy against various gram-positive bacteria, including staphylococci, streptococci, corynebacteria, and clostridia, as well as some gram-negative species such as Neisseria and Haemophilus influenzae. These agents are frequently combined in topical formulations to provide broad-spectrum antibacterial coverage.
Clean the affected area gently before application. Remove debris such as pus or crusts from the affected area. Apply the ointment two to three times daily to the affected skin area.
Suitable for use in children at the same dose as adults, but the dose should be reduced in infants. Not recommended for use in neonates.
Bacitracin Zinc: Increased risk of nephrotoxicity when used with other nephrotoxic drugs. May enhance the action of neuromuscular-blocking agents.
Neomycin Sulphate: Additive nephrotoxic and neurotoxic effects with other aminoglycosides, bacitracin, cisplatin, vancomycin, amphotericin B, polymyxin B, colistin, and viomycin. Enhanced toxicity with potent diuretics. May impair the absorption of other drugs and enhance the effect of acarbose and non-depolarising muscle relaxants. May antagonize the parasympathomimetic effect of neostigmine and pyridostigmine. May increase the risk of hypocalcemia in patients receiving bisphosphonates and alter INR when given with anticoagulants. May inactivate the oral typhoid vaccine.
Hypersensitivity to any of the components.
Keep all medicines out of reach of children. Store in a cool, dry place, protected from light.
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