Fimoxyclav 625mg Tablet

Uses of Fimoxyclav 625mg Tablet

Treats-

• Bacterial Infection 
• Urinary Tract Infection
• Typhoid Fever
• Cystitis
• Prostatitis
• Sinusitis
• Skin Infection
• Bone And Joint Infections

How does Fimoxyclav 625mg Tablet work?

Fimoxyclav 625mg Tablet helps in treating bacterial infection whereas amoxicillin is a penicillin that works by inhibiting the enzymes that help in the synthesis of the integral structural component of the bacterial cell wall whereas clavulanic acid is a beta-lactam (structurally related to penicillin) that works by inactivating an enzyme, namely beta-lactamase, thereby preventing the inactivation of amoxicillin.

Side Effects of Fimoxyclav 625mg Tablet

• Vomiting
• Nausea
• Diarrhea
• Stomach upset
• Skin rashes
• Irritation
• Headache
• Dizziness

Quick Suggestions:

• Complete the course of Fimoxyclav 625mg Tablet given by your doctor. Do not miss any doses and take your medicine on time.
• Fimoxyclav 625mg Tablet is an antibiotic and reserved for specific infections only, do not self-medicate with this medicine. Take proper medical advice before taking this medicine.
• Inform your doctor about all other medicines you take and your medical history if any.
• Diarrhea, nausea, vomiting, and indigestion can be seen as side effects of this medicine, inform your doctor if the side effects do not resolve over time.
• Fimoxyclav 625mg Tablet should be taken as prescribed by your doctor and for the duration, it has been prescribed.

Indication of Fimoxyclav 625mg Tablet

Fimoxyclav 625mg Tablet is commonly prescribed for the treatment of various infections including otitis media (ear infection), sinusitis, lower respiratory tract infections, skin and skin structure infections, and urinary tract infections.

The medication contains two active ingredients: Amoxicillin and Potassium Clavulanate. Amoxicillin is a penicillin antibiotic with a broad spectrum of activity against susceptible bacteria. Potassium Clavulanate is a beta-lactamase inhibitor that helps extend the coverage of Fimoxyclav 625mg Tablet by inhibiting the enzymes produced by certain bacteria that can inactivate amoxicillin.

Fimoxyclav 625mg Tablet is particularly useful when there is amoxicillin resistance present or when patients are unable to tolerate alternative treatments. It is an effective antibiotic that works by inhibiting bacterial cell wall synthesis.

In addition to the aforementioned conditions, Fimoxyclav 625mg Tablet can also be used to treat gonorrhea, tonsillitis, and certain eye, middle ear, or nose infections.

It is important to note that Fimoxyclav 625mg Tablet should not be used to treat viral infections such as colds or the flu, as it is only effective against bacterial infections.

In case of an overdose, symptoms may include neuromuscular hypersensitivity (agitation, hallucinations, asterixis, encephalopathy, confusion, and seizures), as well as electrolyte imbalances with potassium or sodium salts, especially in individuals with renal failure. If an overdose occurs, supportive and symptomatic treatment is typically provided, and hemodialysis may be used to help remove the drug from the bloodstream.

Pharmacology

Pharmacodynamic properties:

Fimoxyclav 625mg Tablet is a combination of two active ingredients, Amoxicillin and Clavulanic Acid. Amoxicillin has broad-spectrum bactericidal activity against a wide range of Gram-positive and Gram-negative microorganisms. However, it is susceptible to degradation by beta-lactamase enzymes produced by certain bacteria, limiting its effectiveness against these bacteria.

Clavulanic Acid is a beta-lactamase inhibitor that can inactivate a wide range of beta-lactamase enzymes produced by bacteria resistant to penicillins and cephalosporins. By combining Amoxicillin with Clavulanic Acid, Fimoxyclav 625mg Tablet protects Amoxicillin from degradation by beta-lactamase enzymes, thereby expanding its antimicrobial spectrum and allowing it to effectively target a broader range of bacteria.

Pharmacokinetic properties:

The pharmacokinetics (absorption, distribution, metabolism, and elimination) of both Amoxicillin and Clavulanic Acid in Fimoxyclav 625mg Tablet are closely linked. Following oral administration, peak serum levels of both components are achieved approximately one hour after dosing. Taking Fimoxyclav 625mg Tablet at the start of a meal optimizes its absorption.

Both Clavulanic Acid and Amoxicillin have low levels of serum protein binding, with approximately 70% remaining free in the serum. Doubling the dose of Fimoxyclav 625mg Tablet approximately doubles the achieved serum levels of the active ingredients.

It is important to note that individual variations in pharmacokinetics can occur, and the dosing and duration of Fimoxyclav 625mg Tablet should be determined by a healthcare professional based on factors such as the specific infection being treated, the patient's age, weight, renal function, and overall health.

Dosage & Administration of Fimoxyclav 625mg Tablet

Dosage for Adults:

• Oral (PO) dosage: One 375mg tablet three times a day is the recommended dosage. In severe infections, the dosage may be increased to one 625mg tablet three times a day or one 1g tablet twice a day.

Hepatic Impairment:

• Caution should be exercised when administering Fimoxyclav 625mg Tablet in individuals with hepatic impairment. Regular monitoring of hepatic function is recommended.

Administration:

• Take Fimoxyclav 625mg Tablet as advised by your physician or healthcare provider.
• Swallow the tablet whole with a glass of water. Do not crush or chew the medicine.
• The correct dose and duration of treatment will be determined by your doctor based on factors such as your age, body weight, and the specific condition being treated.

Interaction

• Prolongation of dying time and prothrombin time: These effects have been reported in a few patients taking Fimoxyclav 625mg Tablet. Prolongation of dying time refers to the time it takes for blood to clot, and prothrombin time is a measure of blood clotting ability. If you are taking Fimoxyclav 625mg Tablet and experience abnormal bleeding or bruising, it is important to inform your doctor.
• Decreased effectiveness of oral contraceptives: Like other broad-spectrum antibiotics, Fimoxyclav 625mg Tablet may decrease the effectiveness of oral contraceptives (birth control pills). It is important to use additional or alternative methods of contraception while taking Fimoxyclav 625mg Tablet.
• Concomitant use of allopurinol: Taking allopurinol (a medication used to treat gout) together with amoxicillin (one of the components of Fimoxyclav) may increase the risk of allergic skin reactions. It is important to exercise caution and inform your doctor if you are taking allopurinol alongside Fimoxyclav 625mg Tablet.
• Drug interactions: Caution should be exercised when Fimoxyclav 625mg Tablet is administered in combination with certain medications, including allopurinol, blood thinners (warfarin), anticancer or anti-arthritis drugs (such as methotrexate), and drugs used to prevent organ transplant rejection (mycophenolate mofetil). It is important to inform your doctor about all the medications you are taking to avoid potential interactions.
• Drug-food interaction: Avoiding high-fat meals while taking Fimoxyclav 625mg Tablet is recommended, as high-fat meals may interfere with the absorption of the medication.
• Drug-disease interaction: Individuals with liver disease (including jaundice), glandular fever, or colitis should not take Fimoxyclav 625mg Tablet. These conditions may affect the metabolism or increase the risk of adverse effects associated with the medication. It is important to inform your doctor about any existing liver disease or other medical conditions before starting treatment.

Contraindications

• Allergy
• Cholestasis
• Liver Disease

Pregnancy & Lactation

Fimoxyclav 625mg Tablet is a medication that contains a combination of Amoxicillin and Clavulanic acid, similar to Fimoxyclav 625mg Tablet. Regarding its use during pregnancy, although animal studies have not shown any teratogenic effects (effects on fetal development), there is limited data available for human pregnancy. Fimoxyclav 625mg Tablet has been taken orally during human pregnancy in a small number of cases without reported adverse effects. However, it is generally not recommended to take Fimoxyclav 625mg Tablet during pregnancy unless it is deemed necessary by your doctor. The potential risks and benefits should be carefully evaluated, and alternative antibiotics may be considered if possible.

It is important to consult your healthcare provider or doctor to discuss your specific situation, and any potential risks, and to determine the most appropriate treatment options during pregnancy.

Regarding breastfeeding, Amoxicillin (one of the components of Fimoxyclav) can be found in trace amounts in breast milk. However, the levels are typically low and are unlikely to cause harm to the nursing infant. If you are breastfeeding and require treatment with Fimoxyclav 625mg Tablet, it is advisable to consult your doctor. They can assess the potential risks and benefits and provide guidance on whether to continue breastfeeding or consider alternatives.

Precautions & Warnings

• If you experience allergy-like symptoms after taking Fimoxyclav 625mg Tablet, such as a rash, swelling of the face/lips/throat, difficulty breathing, or tightness in the chest, it is important to contact your doctor immediately. Allergic reactions can be serious and require prompt medical attention.
• It is crucial not to take Fimoxyclav 625mg Tablet if you have a known allergy to Fimoxyclav 625mg Tablet, penicillin, or cephalosporin antibiotics. Allergic reactions to these medications can range from mild to severe, and it is important to avoid them if you have a known allergy.
• Individuals with liver diseases or jaundice (yellowing of the skin/eyes) should also avoid taking Fimoxyclav 625mg Tablet 10's, as it can have a severe impact on the liver. It is important to inform your doctor about any existing liver conditions before starting this medication.
• If you are pregnant or breastfeeding, it is advisable to consult your doctor before taking Fimoxyclav 625mg Tablet. They will assess the potential risks and benefits of the medication for you and your baby.
• Informing your doctor about all the medications you are currently taking, including over-the-counter drugs and supplements, is essential to avoid any potential interactions or adverse effects. Your doctor can help determine if any adjustments need to be made to your treatment plan.
• Even if you start feeling better after taking Fimoxyclav 625mg Tablet, it is important not to stop taking it until your doctor advises you to do so. Prematurely discontinuing the medication may allow the infection to reappear or worsen due to the development of antibiotic resistance.
• Drinking plenty of fluids when you are sick is generally beneficial. It helps in clearing out the infection more effectively, prevents dehydration, and can alleviate some of the potential side effects of taking Fimoxyclav 625mg Tablet.
• In some cases, individuals may have allergies to Fimoxyclav 625mg Tablet or other medications in the penicillin or cephalosporin antibiotic classes. Prior sensitivity testing may be necessary to determine if you have such an allergy. If you have a known allergy to these antibiotics, it is important to inform your doctor before starting treatment.

Storage Conditions

Store the medicine at or below 25°C in the original package. Keep the medicine out of the reach of children and pets.