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Ceftron 2gm IV Injection
Ceftron injection is used to treat the following major infections:
- Lower respiratory tract infections
- Acute bacterial otitis media
- Skin and skin structure infections
- Urinary tract infections
- Gonorrhea
- Bacterial septicemia
- Bone and joint infections
- Meningitis
- Prevention of postoperative infections
- Perioperative prophylaxis for infections associated with surgery
Note: Always use this medication as directed by a registered physician.
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✅ Description:
Ceftriaxone, a third-generation broad-spectrum cephalosporin antibiotic, exhibits potent bactericidal activity against a wide range of Gram-positive and Gram-negative organisms. It works by interfering with bacterial cell wall synthesis, leading to bacterial death. Ceftriaxone is highly stable against beta-lactamase enzymes. A key feature is its long plasma half-life of 6–9 hours, allowing for once-daily administration in most cases. The drug is not metabolized and is primarily excreted unchanged via urine (40–65%) and bile. Approximately 95% of Ceftriaxone binds to plasma proteins.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Dosage
Adults
- Usual dose: 1–2 g via IV or IM once daily (or divided into two doses).
- Pneumonia, bronchitis, bacterial otitis media, skin infections, urinary tract infections, septicemia, bone/joint infections, meningitis: 1–2 g IV/IM once daily (max: 4 g/day).
- Uncomplicated gonorrhea: 250 mg IM single dose.
- Surgical prophylaxis: 1 g IV single dose, administered 30–120 minutes before surgery.
Infants and Children (1 month and older)
- Usual dose: 50–75 mg/kg IV/IM once daily (or divided into two doses).
- Pneumonia, bronchitis, skin infections, UTIs, septicemia, bone/joint infections: 50–75 mg/kg IV/IM once daily (max: 2 g/day).
- Acute otitis media: 50 mg/kg IM single dose (max: 1 g/day).
- Meningitis: 100 mg/kg IV/IM once daily or divided into two doses (max: 4 g/day).
Duration of Therapy: Continue treatment for at least 2 days after symptoms resolve. Usual duration: 4–14 days (longer for complicated infections).
✔️ Ceftron is generally well-tolerated, but the following side effects may occur:
- Gastrointestinal: Diarrhea, nausea, vomiting, stomatitis, glossitis.
- Skin reactions: Rash, pruritus, urticaria, edema, erythema multiforme.
- Hematological: Eosinophilia, thrombocytopenia, leukopenia, anemia, neutropenia.
- Hepatic: Elevated liver enzymes (SGOT, SGPT), bilirubinemia.
- CNS: Nervousness, confusion, sleep disturbances, headache, hyperactivity, convulsions, dizziness.
- Local: Rare phlebitis after IV administration.
✔️ Administration
Preparation for Intramuscular (IM) Injection:
- Dissolve 250 mg or 500 mg Ceftriaxone in 2 mL Lidocaine HCl (1%) or 1 g Ceftriaxone in 3.5 mL Lidocaine HCl (1%).
Preparation for Intravenous (IV) Injection:
- Dissolve 250 mg or 500 mg Ceftriaxone in 5 mL Water for Injection or 1 g Ceftriaxone in 10 mL Water for Injection.
Administration Guidelines:
- IM or IV injections: Administer over 2–4 minutes.
- IV infusions: Administer over 30 minutes at concentrations of 10–40 mg/mL.
Always perform a test dose to check for patient tolerance before starting treatment. Use freshly prepared solutions for better efficacy, although they remain stable for 6 hours at room temperature or 24 hours at 5°C.
✔️ Interactions
No significant drug interactions have been reported.
Side Effects
Use in Special Populations
Overdose Effects
No specific antidote. Overdose should be managed symptomatically.
Therapeutic Class
Third-generation cephalosporins.
Storage Conditions
✔️ Contraindications
- Hypersensitivity to cephalosporin antibiotics or Ceftriaxone.
✔️ Pregnancy & Lactation
- Pregnancy: Safety in pregnancy has not been established. Use only if necessary.
- Lactation: Ceftriaxone is excreted in low concentrations in breast milk. Use with caution in breastfeeding mothers.
✔️ Precautions & Warnings
- Risk of anaphylactic shock; administer epinephrine and glucocorticoids if needed.
- Rare cases of gallbladder sludge detected on sonograms, reversible upon discontinuation.
- Monitor blood counts during prolonged therapy.
✔️ Storage:
Store vials in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
