Teana Plus (Telmisartan and Hydrochlorothiazide) is used for managing hypertension (high blood pressure). It can be taken alone or combined with other antihypertensive drugs. By lowering blood pressure, it helps reduce the risk of fatal and nonfatal cardiovascular events, especially strokes and heart attacks.
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Telmisartan: Angiotensin II, formed from angiotensin I, is a key agent in the renin-angiotensin system that causes vasoconstriction and stimulates aldosterone release, increasing blood pressure. Telmisartan works by blocking the binding of angiotensin II to the AT1 receptor, thus preventing vasoconstriction and reducing blood pressure. It selectively targets the AT1 receptor and has a much stronger affinity for it compared to the AT2 receptor.
Hydrochlorothiazide: This thiazide diuretic increases the excretion of sodium and chloride from the kidneys. It indirectly lowers blood pressure by reducing plasma volume, which raises renin and aldosterone levels, leading to increased potassium loss. The addition of an ARB like Telmisartan helps counterbalance the potassium loss caused by hydrochlorothiazide.
Teana Plus 40 is a combination of Telmisartan and Hydrochlorothiazide, which work together to effectively lower blood pressure.
Telmisartan is an angiotensin receptor blocker (ARB) that blocks the action of angiotensin II, a hormone that causes blood vessels to constrict. By blocking this hormone, Telmisartan helps relax the blood vessels, allowing blood to flow more smoothly and reducing blood pressure.
Hydrochlorothiazide is a diuretic (water pill) that helps remove excess water and salt from the body. Over time, it also relaxes blood vessels, improving blood flow and helping to lower blood pressure.
Signs of overdose include low blood pressure, dizziness, tachycardia, bradycardia, electrolyte imbalances (e.g., hypokalemia, hyponatremia), and dehydration. Telmisartan is not removed by hemodialysis.
Be cautious when taking Teana Plus with medications like aliskiren, digoxin, lithium, other blood pressure drugs, NSAIDs (e.g., ibuprofen), corticosteroids, ACE inhibitors (e.g., enalapril), and other angiotensin II receptor blockers. Teana Plus may interfere with certain lab tests, potentially leading to false results.
Do not use Teana Plus if you are allergic to Telmisartan, Hydrochlorothiazide, or any other ingredient in the drug. It should not be co-administered with Aliskiren in diabetic patients.
Store in a cool, dry place, protected from light, and out of reach of children.
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