Osartil 100 Plus (30Pcs Box)

Indication

A pair of medications are combined in Osartil Plus 100/25. Various methods are used to control high blood pressure. Untreated high blood pressure can cause heart attacks, strokes, and kidney failure. Osartil Plus 100/25 may be taken either with or without food. Your illness and how you react to the medication will determine the dosage. Try to take it every day at the same time. It is crucial to continue taking this medication unless your doctor instructs you otherwise.

Pharmacology

Angiotensin II receptor antagonists include losartan. Through selective and competitive blocking of the vasoconstriction of angiotensin II and aldosterone secretion, it selectively antagonizes the binding of angiotensin II and the AT1 receptor. As a result of hydrochlorothiazide's ability to prevent the reabsorption of sodium in the distal tubule, more sodium, water, potassium, and hydrogen ions are excreted.

Dosage & Administration

Hypertension-

• A tablet of 50/12.5 is typically used once daily as the initial dose.
• If a patient's response to one tablet is inadequate, the dosage can be raised to 100/25 once daily.
• A patient's blood pressure may be shifted to this combination of 100/12.5 once daily if it is not properly controlled with Losartan 100 mg monotherapy.
• The initial dose for hypertensive individuals with left ventricular hypertrophy is 50/12.5, and if further blood pressure lowering is required, 100/12.5 may be administered, followed by 100/25. 100/25 is the maximum dose, given once daily.
• Generally, three weeks after therapy begins, the antihypertensive effect is realized.
  For older patients, the initial dosage adjustment of 50/12.5 is not required.
• The first course of treatment for older people should not, however, employ a maximum dose of 100/25 once a day.

Severe Hypertension:

• The starting dose for initial treatment of severe hypertension is one tablet of 50/12.5 once daily.
• For patients who do not respond adequately to this dose after 2 to 4 weeks of therapy, the dosage may be increased to 100/25 once daily. The maximum dose is one tablet of 100/25 once daily.

This medication can be combined with other antihypertensive medications. This medication can be used with or without food.

Interaction

Losartan Potassium: Drug-drug pharmacokinetic interactions with Hydrochlorothiazide, Digoxin, Warfarin, Cimetidine, and Phenobarbital were not found to be significantly harmful. Similar to other drugs that block angiotensin II or its effects, concurrent use of potassium-sparing diuretics (such as Spironolactone, Triamterene, and Amiloride), potassium supplements, or salt substitutes containing potassium may result in a rise in serum potassium. The nonsteroidal anti-inflammatory medicine Indomethacin can lessen the antihypertensive effects of losartan, similar to other antihypertensive medications.

Alcohol, barbiturates, and narcotics may potentiate orthostatic hypotension when used along with Thiazide diuretics.

Antidiabetic medicines (oral agents and Insulin): antidiabetic drug dosage may need to be adjusted.

Other antihypertensive drugs: potentiation or additive effect

Cholestyramine with colestipol resins: Hydrochlorothiazide absorption is hampered when anionic exchange resins are present.

Contraindications

The use of Losartan and Hydrochlorothiazide together is not advised in patients who are hypersensitive to either drug. Due to the Hydrochlorothiazide component, this drug is contraindicated in patients who have anuria or hypersensitivity to other medications derived from sulfonamides.

Side Effects

• Nausea
• Taste change
• Upset stomach
• Diarrhea
• Headache
• Dizziness
• Weakness
• Decreased blood pressure
• Glucose intolerance
• Electrolyte imbalance
• Increased blood uric acid
• Increased blood lipid level

Pregnancy & Lactation

Unless absolutely necessary, angiotensin-II receptor antagonists should be avoided during pregnancy. They have been linked to prenatal and newborn blood pressure management and renal function, as well as skull abnormalities and oligo hydrinos. There is a scarcity of information on the use of angiotensin-II receptor antagonists during breastfeeding. They are not indicated while nursing, and there are alternative therapy choices with better-established safety information.

Precautions & Warnings

• Angioedema: hypersensitivity
• At regular intervals, serum electrolyte measurement should be performed to detect probable electrolyte imbalance.
• Hypokalemia is an uncommon complication that can occur with brisk diuresis, severe cirrhosis, or long-term medication.
• Renal impairment and symptomatic hypotension
• Osartil Plus 100 could make you thirsty. Be sure to stay hydrated and let your doctor know if you have severe thirst, a dry mouth, or muscle weakness.
  It might make you queasy. When getting out of a seated or lying down position, move slowly.

Storage Conditions

Do not store at temperatures above 30°C. Keep out of children's reach.