Amlopin 5mg Tablet 1 Strip

✔️ Dosage and Administration of Amlopin 5

Hypertension

• Recommended starting dose: 5 mg once daily.
• Maximum dose: 10 mg once daily.
• Elderly patients or those with liver impairment may begin with 2.5 mg once daily.
• The lower dose may also be used when Amlopin is added to existing antihypertensive therapy.

Angina (Chronic Stable or Vasospastic)

• Recommended dose: 5–10 mg once daily.
• Lower doses are generally preferred for elderly patients and those with hepatic impairment.
• Most patients achieve adequate control with 10 mg daily.

Administration

• Amlopin may be taken with or without food.
• Always use the medication according to the advice of a registered physician.

✔️ Interaction

Potentially Significant Interactions

• In patients with severely impaired left ventricular function, combining Amlopin with beta-blockers should be approached cautiously due to limited safety data.

Other Interactions

• Digoxin: No clinically significant interaction has been observed.
• Cimetidine: Studies indicate no meaningful interaction.
• Warfarin: Amlopin does not significantly affect the anticoagulant action of warfarin.
• Food: Food intake does not affect the absorption of Amlopin.

✔️ Amlopin should not be used in:

• Individuals with hypersensitivity to amlodipine or other dihydropyridine derivatives.
• Pregnant women unless specifically advised by a physician after careful evaluation.

✔️ Dosage & Administration

Children (6–17 Years)

• Starting dose: 2.5 mg once daily.
• May be increased to 5 mg daily if blood pressure remains uncontrolled after four weeks.
• Doses above 5 mg daily have not been adequately studied.

Children Below 6 Years

• The effects of amlodipine on blood pressure in this age group have not been established.

Elderly Patients

• Amlopin is generally well tolerated at standard doses.
• Dose increases should be made gradually and with caution.

Renal Impairment

• No dosage adjustment is usually required.
• Plasma levels are not significantly affected by the degree of kidney dysfunction.
• Amlodipine cannot be removed by dialysis.

Hepatic Impairment

• Dose recommendations for mild to moderate liver disease are not well defined.
• Treatment should begin at the lowest effective dose and be adjusted carefully.
• Patients with severe liver impairment should start with 2.5 mg once daily and undergo gradual dose titration.

✔️ Side Effects

Common side effects are mainly related to blood vessel dilation and may include:

• Dizziness
• Flushing
• Headache
• Low blood pressure (hypotension)
• Swelling of the ankles or legs (peripheral edema)

Other possible side effects include:

• Gastrointestinal disturbances
• Increased frequency of urination
• Fatigue or lethargy
• Eye pain
• Depression or mood changes

Rarely, treatment may initially worsen angina symptoms. Excessive lowering of blood pressure can occasionally lead to reduced blood flow to the brain or heart, resulting in temporary visual disturbances or ischemic events. Allergic reactions may cause:

• Skin rashes
• Fever
• Abnormal liver function tests

✔️ Overdose

Symptoms
An overdose may cause:

• Excessive widening of blood vessels
• Rapid heart rate (reflex tachycardia)
• Severe and prolonged low blood pressure
• Circulatory shock, which may be life-threatening

Management
Treatment includes:

• Continuous monitoring of cardiovascular and respiratory function
• Elevation of the legs
• Maintenance of adequate fluid balance and urine output
• Administration of vasoconstrictor agents when appropriate
• Intravenous calcium gluconate to counteract calcium channel blockade
• Gastric lavage in selected cases
• Activated charcoal, if given within two hours of ingestion, may reduce drug absorption

Because amlodipine is highly protein-bound, dialysis is unlikely to be effective.

✔️ Storage:

• Store in a cool, dry place away from direct light.
• Keep all medicines out of the reach of children.