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Verquv is a preparation of Vericiguat, which is a stimulator of soluble guanylate cyclase (sGC), an important enzyme in the nitric oxide (NO) signaling pathway. When NO binds to sGC, the enzyme catalyzes the synthesis of intracellular cyclic guanosine monophosphate (cGMP), a second messenger that plays a role in the regulation of vascular tone, cardiac contractilit,y and cardiac remodeling. Heart failure is associated with impaired synthesis of NO and decreased activity of sGC, which may contribute to myocardial and vascular dysfunction. By directly stimulating sGC, independently of and synergistically with NO, Verquv® augments levels of intracellular cGMP, leading to smooth muscle relaxation and vasodilation.
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✅ Description:
Packing
Verquv 2.5 tablet: Carton of 30 tablets in blister pack.
Verquv 5 tablet: Carton of 30 tablets in blister pack.
Verquv 10 tablet: Carton of 30 tablets in blister pack.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Indications:
Verquv is indicated to reduce the risk of cardiovascular death and heart failure (HF) hospitalization following a hospitalization for heart failure or need for outpatient IV diuretics, in adults with symptomatic chronic HF and ejection fraction less than 45%.
Dosage and administration
Precautions
Special waming: Embryo-Fetal Toxicity
Vericiguat may cause fetal harm when administered to a pregnant woman. Obtain a pregnancy test before the start of treatment. Advise females of reproductive potential of the potential risk to a fetus, to use effective contraception during treatment with vericiguat and for at least one month after the final dose.
Side effects
Most common side effects are hypotension and anemia.
Contraindications
Vericiguat is contraindicated in patients with known hypersensitivity to it or any other components of this product. It is also contraindicated in patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators and in pregnancy.
Drug interactions
Drug interaction with medication: Vericiguat is not recommended in patients with concomitant use of other soluble guanylate cyclase (sGC) stimulators. Concomitant use of vericiguat with PDE-5 inhibitors is not recommended because of the potential for hypotension.
✔️ Use in pregnancy & lactation
Pregnancy: Vericiguat may cause fetal harm when administered to a pregnant woman and is contraindicated during pregnancy.
Lactation: There are no data on the presence of vericiguat in human milk, the effects on the breastfed infant, or the effects on milk production. Because of the potential for serious adverse reactions in breastfed infants from vericiguat, advise women not to breastfeed during treatment with vericiguat.
✔️ Route of administration:
Verquv should be taken in oral route with food. For patients who are unable to swallow whole tablets, Verquv® may be crushed and mixed with water immediately before administration or as directed by the physician. The recommended starting dose of Verquv is 2.5 mg once daily. Double the dose of Verquv approximately every 2 weeks to reach the target maintenance dose of 10 mg once daily, as tolerated by the patient.
✔️ Storage
Store below 30°C in a dry place, protected from light. Keep away from the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
