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Pansec 40mg 14pcs Tablet
Pantoprazole is a proton pump inhibitor that targets the H+/K+ ATPase enzyme system in gastric parietal cells. By irreversibly binding to the enzyme, it blocks the final step in gastric acid production, reducing both basal and stimulated acid secretion for more than 24 hours.
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✅ Description:
Pantoprazole, a proton pump inhibitor (PPI), is effective in conditions requiring suppression of gastric acid secretion. It is indicated for:
- Peptic Ulcer Disease: Both gastric and duodenal ulcers.
- Gastroesophageal Reflux Disease (GERD): Especially in patients with associated erosive esophagitis.
- NSAID-Associated Ulceration: Prevents and treats ulcers caused by prolonged NSAID use.
- Helicobacter pylori Eradication: Used in combination with antibiotics to treat ulcers associated with H. pylori infection.
- Zollinger-Ellison Syndrome: A condition characterized by excessive gastric acid production.
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✔️ Dosage and Administration of Pansec 40
Oral Administration
- Benign Gastric Ulcers: 40 mg once daily in the morning for 4 weeks, with an additional 4 weeks if healing is incomplete.
- GERD: 20-40 mg once daily in the morning for 4 weeks, extendable by another 4 weeks if required. Maintenance dose: 20 mg daily, which can be increased to 40 mg.
- Duodenal Ulcers: 40 mg daily in the morning for 2 weeks, extendable by another 2 weeks if necessary.
- H. pylori Eradication:
- 40 mg twice daily with:
- Amoxicillin (1 g) and Clarithromycin (500 mg) twice daily for one week, or
- Clarithromycin (250 mg) and Metronidazole (400 mg) twice daily for one week.
- 40 mg twice daily with:
- NSAID-Associated Ulcers: Prophylactic dose: 20 mg daily for patients requiring long-term NSAID therapy.
- Zollinger-Ellison Syndrome: Initial dose of 80 mg daily, adjusted based on patient response. Elderly patients should not exceed 40 mg daily.
✔️ Side Effects of Pansec 40
Common Side Effects (1-10%):
- Headache (>4%)
- Abdominal pain (4%)
- Diarrhea (4%)
- Constipation (<4%)
- Nausea and vomiting (>4%)
- Rash (4%)
- Pruritus (4%)
Rare Side Effects:
- Hyperglycemia (1%)
- Flatulence (<4%)
- Photosensitivity (<2%)
- Facial or generalized edema (<4%)
Serious Reactions:
- Angioedema, Stevens-Johnson syndrome, and Toxic Epidermal Necrolysis: Rare but potentially fatal hypersensitivity reactions.
- Pancytopenia and Interstitial Nephritis: Requires close monitoring.
- Hepatocellular Damage: May lead to liver failure in rare cases.
- Pancreatitis, Rhabdomyolysis: Rare but serious adverse events.
✔️ Special Populations
- Elderly: No dosage adjustment is required unless clinically indicated.
- Hepatic Impairment: Limit dose to 20 mg/day or 40 mg every other day.
- Renal Impairment: No dosage adjustment is necessary.
✔️ Drug Interactions
- Increased Risk of Hypomagnesemia: With diuretics.
- Delayed Absorption: Co-administration with sucralfate can reduce the absorption of pantoprazole.
- Warfarin: May increase INR and prothrombin time, necessitating monitoring.
- Methotrexate and Saquinavir: May increase serum concentrations.
- Ketoconazole and Itraconazole: Decreased absorption.
- Rilpivirine, Atazanavir, Nelfinavir: May significantly reduce serum levels and therapeutic effects.
✔️ Contraindications
- Known hypersensitivity to any formulation component.
- Concomitant use with rilpivirine, atazanavir, or nelfinavir.
✔️ Gastric Malignancy:
- Rule out malignancy before starting treatment, as symptoms may mask cancer.
✔️ Long-Term Use Risks:
- May lead to Vitamin B12 deficiency due to impaired absorption.
- Can increase the risk of osteoporosis-related fracture
✔️ Pregnancy and Lactation
- Pregnancy: Classified as Category B. No evidence of harm in animal studies, but use only if necessary.
- Lactation: Pantoprazole is excreted in breast milk. Consider discontinuing either the drug or breastfeeding based on clinical need.
✔️ Storage Conditions
- Store in a cool, dry place away from light and heat.
- Keep out of reach of children.
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