Antanil Plus Suspension

Aluminium hydroxide gel 400mg, magnesium hydroxide 400mg & simethicone 30mg/5ml: suspension is indicated for symptomatic relief of hyperacidity associated with the peptic ulcer, gastritis, peptic oesophagitis, gastric hyperacidity, heartburn, sour stomach or hiatus hernia. It is effective in the prevention of stress ulceration and GI bleeding. It acts as an antiflatulent to alleviate the symptoms of gas, including postoperative gas pain. This rapidly relieves acid pain, disperses gastric foam, and facilitates eructation of gas and air.

This is a mixture of non-systemic acid-neutralizing substances and antiflatulent. This preparation offers reliability as well as long action. Aluminium Hydroxide and Magnesium Hydroxide induce the relief of ulcer by neutralizing gastric acid secreted from parietal cells of the stomach. The clinical use of simethicone is based on its antifoam properties. Simethicone spreads on the surface of aqueous liquids, forming a film of low surface tension and causing the collapse of foam bubbles. Simethicone repeatedly allows mucous-surrounded gas bubbles in the GI tract to coalesce and be expelled.

This is used in the treatment of flatulence and meteorism for the elimination of gas, air, or foam from the gastrointestinal tract before radiography and for the relief of abdominal distension and dyspepsia.

Simethicone is physiologically inert; it does not appear to be absorbed from the GI tract to interfere with gastric secretion or absorption of nutrients. Following oral administration, the drug is excreted unchanged in the feces.

1-2 teaspoonfuls 1-3 hours after a meal and at bedtime or as directed by the physician.

All antacids may increase or decrease the rate and/or extent of absorption of concomitantly administered oral drugs. Antacids decrease the bioavailability of theophylline, tetracycline, quinolone antibiotics, isoniazide, ketoconazole, ethambutol, some antimuscarinic drugs, benzodiazepines, phenothiazines, ranitidine, indomethacin, nitrofurantoin, fluoride, phosphate, propanolol, atenolol, digoxin, vitamins, etc. Antacids increase the bioavailability of some drugs, e.g., sulphonamides, levodopa, valproic acid, enteric-coated aspirin, etc.

This should not be administered in patients with renal failure or hypophosphataemia or in those who are severely debilitated. It is also contraindicated in alkalosis and hypermagnesaemia, where abdominal distention may be due to partial or complete intestinal obstruction.

Gastrointestinal side effects are uncommon. Occasionally, if an excessive amount is consumed, diarrhea, constipation, or regurgitation may occur.

It is advised to avoid antacid preparations in the first trimester of pregnancy.

This should be used with caution in patients with kidney disease.

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.