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Micoderm Cream is prescribed for various fungal skin infections (dermatomycoses) including:
- Athlete’s foot (Tinea pedis)
- Ringworm of the body (Tinea corporis)
- Fungal infections of the hand (Tinea manuum)
- Jock itch (Tinea cruris) caused by Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum audouinii, Epidermophyton floccosum
- Candidiasis (yeast infections)
- Tinea versicolor
- Inflamed skin folds (intertrigo)
- Perianal fungal infections
- Angular stomatitis (cheilitis)
- Balanoposthitis
- Otitis externa (outer ear infections)
Micoderm Cream also provides rapid relief from itching (pruritus) often associated with fungal infections.
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✅ Description:
Pharmacodynamics:
Miconazole exhibits potent antifungal action against common dermatophytes and yeasts and also possesses antibacterial activity against some gram-positive organisms. It works by inhibiting an essential step in the production of ergosterol, a key component of the fungal cell membrane. The absence of ergosterol disrupts membrane integrity, leading to leakage of essential intracellular contents and cell death.
Pharmacokinetics:
Orally, miconazole has limited absorption (about 25–30%). When administered as an oral gel, it is partly absorbed and binds strongly to plasma proteins, mainly serum albumin and red blood cells. It undergoes hepatic metabolism, with less than 1% excreted unchanged in urine. The average elimination half-life ranges from 20 to 25 hours, with similar clearance in patients with kidney impairment.
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✔️ Dosage & Administration
Miconazole Cream
- Apply to affected areas twice daily (morning and evening) for tinea infections and cutaneous candidiasis, and once daily for tinea versicolor.
- In skin fold areas, apply sparingly and massage well to avoid skin softening (maceration).
- Symptom relief usually begins within 2–3 days, and infections typically clear within 2–5 weeks.
- To prevent recurrence, continue treatment 10 days after symptom resolution.
- Treat Candida, tinea corporis, and cruris for 2 weeks, and tinea pedis for 4 weeks.
✔️ Side Effects
Rare: Nausea, vomiting, diarrhea, especially with long-term use.
Occasionally, Allergic skin reactions.
✔️ Drug Interactions
Avoid combining with terfenadine, astemizole, or cisapride, as miconazole may inhibit their metabolism and elevate toxicity risk.
May also increase blood levels of phenytoin and cyclosporine, necessitating monitoring.
✔️ Contraindications
Do not use in individuals with known allergy or hypersensitivity to miconazole or any component of the formulation.
✔️ Use in Pregnancy & Lactation
- Safety during pregnancy has not been fully established—use only if needed and prescribed.
- Exercise caution during breastfeeding, as many medications may be excreted in breast milk.
✔️ Precautions & Warnings
- When co-administered with anticoagulants, monitor bleeding risk and adjust dosage as needed.
- Monitor levels of phenytoin and cyclosporine when used concurrently.
- In infants and small children, ensure the gel does not block the throat.
✔️ Storage
Store in a cool, dry place away from heat and light. Keep out of children’s reach.
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information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
