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Valepsy Syrup 100ml
- Sodium Valproate, the active ingredient, is an anti-epileptic medication. Its mechanism of action is not fully understood but is believed to increase brain levels of gamma-aminobutyric acid (GABA), which has inhibitory effects on nerve activity, helping to control seizures.
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✅ Description:
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✔️ Valepsy is used to treat various types of epilepsy, including:
- Partial seizures
- Absence of seizures (petit mal)
- Generalized tonic-clonic seizures (grand mal)
- Myoclonic seizures
- Atonic seizures
- Mixed seizures, including absence attacks
- Prophylaxis of febrile convulsions
- Prophylaxis of post-traumatic epilepsy
Additionally, it is used in the treatment of bipolar disorder and for the prophylaxis of migraine.
✔️ Composition:
- Sodium Valproate Tablets: Each enteric-coated tablet contains 200 mg of Sodium Valproate BP.
- Sodium Valproate Syrup: Each 5 ml syrup contains 200 mg of Sodium Valproate BP.
- Sodium Valproate Controlled-Release Tablets:
- 200 mg tablet contains 133.2 mg Sodium Valproate & 58 mg Valproic acid.
- 300 mg tablet contains 199.8 mg Sodium Valproate & 87 mg Valproic acid.
- 500 mg tablet contains 333 mg Sodium Valproate & 145 mg Valproic acid.
- Sodium Valproate Injection: Each 5 ml injectable solution contains 500 mg of Sodium Valproate (equivalent to Valproic Acid 500 mg).
✔️ Side Effects: Valepsy Syrup
- Common: Anorexia, nausea, vomiting, sedation, ataxia, tremor, rash, alopecia, increased appetite.
- Hepatic effects: Elevated liver enzymes in plasma, potential for fulminant hepatitis, particularly in children under 2 years or those on multiple antiepileptic drugs.
- Pancreatitis and hyperammonemia may also occur.
✔️ Dosage: Valepsy Syrup
Epilepsy:
- Adults: Start with 600 mg daily (divided doses), increasing by 200 mg/day at 3-day intervals up to a maximum of 2.5 g/day.
- Children (over 20 kg): Start with 400 mg daily, increasing to control seizures (max 35 mg/kg/day).
- Children (up to 20 kg): Start with 20 mg/kg/day in divided doses.
Febrile Convulsions: 20-30 mg/kg/day in divided doses.
Bipolar Disorder: Start with 600 mg daily in 2-3 divided doses; maintenance dose is 1000-2000 mg/day.
Migraine Prophylaxis: 400-600 mg daily, with some requiring 1000-1500 mg/day.
✔️ Interaction:
Sodium Valproate may inhibit drug metabolism and interact with medications like Phenobarbital, Phenytoin, Warfarin, and Aspirin.
✔️ Contraindications:
- Hypersensitivity to Sodium Valproate or liver dysfunction.
- Not recommended for pregnant women or women of childbearing potential.
✔️ Pregnancy & Lactation:
- Pregnancy: Valproate is associated with neural tube defects (e.g., spina bifida) if taken during the first trimester. Women should be offered screening for α-fetoprotein levels.
- Lactation: Excreted in breast milk, but no significant risk to infants has been observed.
✔️ Precautions & Warnings:
- Monitor liver function before and during the first 6 months, especially for at-risk patients.
- Exercise caution in cases of renal impairment, pregnancy, breastfeeding, and systemic lupus erythematosus.
- Avoid sudden withdrawal of therapy, which could cause seizures.
✔️ Storage:
Store below 30°C, away from light and out of reach of children.
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