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Levefix 500 Tablet 1 Strip
Levetiracetam 500 Tablet
Monotherapy:
- For newly diagnosed epilepsy in adults and adolescents (≥16 years) with partial-onset seizures (with or without secondary generalization).
Adjunct Therapy:
- Partial-onset seizures in adults, adolescents, children, and infants (from 1 month of age).
- Myoclonic seizures in patients ≥12 years with Juvenile Myoclonic Epilepsy.
- Primary generalized tonic-clonic seizures in patients ≥12 years with Idiopathic Generalized Epilepsy.
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✅ Description:
Though not fully understood, Levefix is thought to inhibit hypersynchronous burst firing and seizure propagation without affecting normal neuronal excitability. This selective inhibition may explain its antiepileptic effect.
Infants (1 month–6 months):
Oral solution only
Tablets should be swallowed whole with liquid, taken twice daily, with or without food.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Overdose Management
- Symptoms: Drowsiness, agitation, confusion, respiratory depression, coma
- No specific antidote
- Management: Gastric lavage/emesis, symptomatic treatment, hemodialysis (removes ~60% of the drug)
✔️ Dosage & Administration of Levefix Tablet
Adults & Adolescents (≥16 years)
- Starting dose: 250 mg twice daily
- Maintenance: 500 mg twice daily (after 2 weeks)
- Maximum: 1500 mg twice daily
- Titrate by 250 mg every 2 weeks based on response
Adults (≥18 years) & Adolescents (12–17 years) ≥50 kg
- Start with 500 mg twice daily
- May increase to 1500 mg twice daily
- Dose changes by 500 mg can be made every 2–4 weeks
Pediatrics
- Children <6 years: Use oral solution
- Children 6–11 years or <25 kg: Use solution for accurate dosing
- Children ≥25 kg: Start with 250 mg twice daily, max 750 mg twice daily
- Children ≥50 kg: Same dosage as adults
Elderly: Dose adjustment may be necessary based on kidney function
Children <6 years: Tablets not suitable—use solution
Note: Monotherapy has not been established for children under 16
✔️ Side Effects of Levefix Tablet
Adults: Drowsiness, fatigue, dizziness, infections
Pediatrics: Fatigue, irritability, nasal congestion, aggression, appetite loss
✔️ Drug Interactions
No known interactions with common antiepileptic drugs (e.g., phenytoin, valproate, carbamazepine)
- Probenecid: May reduce renal clearance of metabolite (not clinically significant)
- Methotrexate: May increase methotrexate levels—monitor closely
- Laxatives (macrogol): May reduce Levefix efficacy—avoid within 1 hour before/after dosing
- Food: No effect on extent of absorption; slight delay in onset
- Alcohol: No conclusive data
✔️ Contraindications
Known hypersensitivity to levetiracetam, other pyrrolidone derivatives, or excipients
✔️ Pregnancy & Lactation
Not recommended unless necessary in pregnant or non-contraceptive women of childbearing potential
Excreted in breast milk—avoid breastfeeding unless the benefit outweighs the risk
No adverse effect on fertility was seen in animal studies
✔️ Precautions & Warnings
- Renal Impairment: Dose adjustment required based on renal function
- Liver Impairment: In severe cases, reduce dose if CrCl <60 ml/min
- Blood Dyscrasias: Monitor CBC if the patient has weakness, fever, or recurrent infections
- Suicidality: Watch for suicidal thoughts/behavior; monitor mood
- Acute Kidney Injury: Rare but possible
- Pediatrics: Long-term effects on development are still under study
✔️ Storage
- Store in a cool, dry place, below 25°C, protected from light and moisture
- Keep out of children’s reach
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
