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Epicure 50mg Tablet 1 Strip
Epicure (Brivaracetam)
- Treatment of partial onset seizures in patients aged 1 month and older.
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✅ Description:
- Brivaracetam is an anticonvulsant with a high and selective affinity for synaptic vesicle protein 2A (SV2A) in the brain, which may contribute to its anticonvulsant effect. The exact mechanism is not fully understood.
✔️ Side Effects:
- Common side effects: Nausea, vomiting, constipation, somnolence, dizziness, fatigue, coordination and balance disturbances, and irritability.
✔️ Dosage & Administration
- Adults (16 years and older):
- Initial dose: 50 mg twice daily (100 mg/day).
- Maintenance dose: 25 mg to 100 mg twice daily (50 mg to 200 mg/day).
- Pediatric patients (50 kg or more):
- Initial dose: 25 mg to 50 mg twice daily (50 mg to 100 mg/day).
- Maintenance dose: 25 mg to 100 mg twice daily (50 mg to 200 mg/day).
- Pediatric patients (20 kg to less than 50 kg):
- Initial dose: 0.5 mg/kg to 1 mg/kg twice daily (1 mg/kg to 2 mg/kg/day).
- Maintenance dose: 0.5 mg/kg to 2 mg/kg twice daily (1 mg/kg to 4 mg/kg/day).
- Pediatric patients (11 kg to less than 20 kg):
- Initial dose: 0.5 mg/kg to 1.25 mg/kg twice daily (1 mg/kg to 2.5 mg/kg/day).
- Maintenance dose: 0.5 mg/kg to 2.5 mg/kg twice daily (1 mg/kg to 5 mg/kg/day).
- Pediatric patients (less than 11 kg):
- Initial dose: 0.75 mg/kg to 1.5 mg/kg twice daily (1.5 mg/kg to 3 mg/kg/day).
- Maintenance dose: 0.75 mg/kg to 3 mg/kg twice daily (1.5 mg/kg to 6 mg/kg/day).
- Geriatric Use: Start at the low end of the dosing range.
- Renal Impairment: No dose adjustment needed except for patients with end-stage renal disease undergoing dialysis.
✔️ Drug Interactions:
- Rifampin: May decrease Epicure plasma concentrations; increase dose by up to 100%.
- Carbamazepine: May increase exposure to carbamazepine-epoxide; dose reduction may be needed.
- Phenytoin: Monitor phenytoin levels as Epicure may increase plasma concentrations.
- Levetiracetam: No added benefit when used with Brivaracetam.
✔️ Contraindications:
Contraindicated in patients with hypersensitivity to Brivaracetam or any other components of the product.
✔️ Pregnancy & Lactation:
- Pregnancy: Only use if the benefit to the mother outweighs the risk to the fetus.
- Lactation: Unknown if Brivaracetam is excreted in human milk. Weigh the benefits of breastfeeding against potential risks.
✔️ Precautions & Warnings:
- Suicidal Thoughts/Behavior: AEDs like Brivaracetam increase the risk; monitor for mood changes and suicidal thoughts.
- Somnolence & Coordination Disturbances: May cause dizziness, fatigue, and coordination issues; avoid driving or operating machinery.
- Psychiatric Reactions: Includes irritability, anxiety, aggression, psychosis, hallucinations, and mood swings.
- Gradual Withdrawal: To avoid increased seizure frequency, it should be withdrawn gradually.
✔️ Storage Conditions:
- Store below 30°C in a cool, dry place, protected from light. Keep away from children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
