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Vintelix 5mg Tablet 1 Strip
Vintelix (Vortioxetine Hydrobromide)
Therapeutic Class: Serotonin-Norepinephrine Reuptake Inhibitor (SNRI). Vintelix is prescribed for the treatment of Major Depressive Disorder (MDD) in adults.
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✅ Description:
Vortioxetine’s exact antidepressant mechanism is not fully known. However, its action is believed to stem from enhancing serotonergic activity by inhibiting serotonin (5-HT) reuptake. Additionally, it exhibits 5-HT3 receptor antagonism and 5-HT1A receptor agonism, contributing to its therapeutic effects in MDD.
✔️ Dosage & Administration of Vintelix 5
- Starting Dose: 10 mg orally once daily, with or without food.
- Dose Adjustment: May be increased to 20 mg/day if tolerated.
- Minimum Dose: For patients with intolerance, reduce to 5 mg/day.
- Elderly Patients (>65 years): Begin with the lowest dose of 5 mg/day.
- Maintenance Treatment: Long-term use may be required; reassess periodically.
- Discontinuation: For patients on 15–20 mg/day, reduce to 10 mg/day for one week before stopping to reduce withdrawal symptoms such as headache and muscle tension.
- Switching from/to MAOIs: Allow a 14-day gap when transitioning from MAOIs to Vintelix and a 21-day interval when switching from Vintelix to MAOIs.
Special Populations
- Pediatrics (<18 years): Safety and efficacy not established.
- Elderly (>65 years): No dose adjustment needed beyond starting at 5 mg/day.
- Renal Impairment: No dose adjustment required.
- Hepatic Impairment: Not recommended in severe impairment; no dose change for mild to moderate cases.
- CYP2D6 Poor Metabolizers: Vortioxetine exposure may be doubled—adjust dose if used with strong CYP3A4/2C9 inhibitors.
- No dose adjustments necessary based on race, sex, or ethnicity.
✔️ Adverse Effects of Vintelix 5
Possible side effects include:
- Hypersensitivity reactions
- Suicidal thoughts or behavioral changes
- Serotonin syndrome
- Abnormal bleeding
- Mania or hypomania activation
- Angle-closure glaucoma
- Hyponatremia (low sodium levels)
✔️ Drug Interactions
- MAO Inhibitors: Risk of severe or fatal reactions if combined; contraindicated.
- Serotonergic Agents: Combining with SSRIs, SNRIs, Tramadol, Triptans, Buspirone, or Tryptophan may trigger serotonin syndrome. Discontinue both drugs immediately if symptoms occur.
- Lithium: No significant interaction observed.
- CYP2D6 Inhibitors (e.g., Bupropion, Fluoxetine, Paroxetine): Reduce Vintelix dose by 50%.
- CYP Inducers (e.g., Rifampin, Phenytoin, Carbamazepine): Consider dose increase of Vintelix.
✔️ Use in Pregnancy and Lactation
- Pregnancy: Not recommended unless benefits outweigh risks.
- Lactation: Vortioxetine and its metabolites may pass into breast milk. Breastfeeding is discouraged during therapy due to unknown risks to the infant.
✔️ Warnings and Precautions
- Suicidality: Monitor all patients for mood worsening or suicidal behavior, especially in early treatment or during dose changes.
- Serotonin Syndrome: May occur when used alone or with serotonergic or MAOI agents; discontinue immediately if symptoms develop.
- Bleeding Risk: Use cautiously with anticoagulants (e.g., Warfarin), NSAIDs, or Aspirin.
- Mania/Hypomania: Use cautiously in patients with a history or family history of bipolar disorder.
- Angle-Closure Glaucoma: Pupillary dilation may trigger attacks in patients with narrow angles.
- Hyponatremia: Monitor elderly and those on diuretics or prone to low sodium.
✔️ Storage Conditions
- Store below 30°C in a dry, dark place.
- Keep away from children.
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