Florest is indicated in-
It is also indicated in-
Fluvoxamine maleate should be avoided in pregnancy and lactation.
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Fluvoxamine blocks the reuptake of serotonin at the serotonin reuptake pump of the neuronal membrane, enhancing the actions of serotonin on 5HT1A autoreceptors. Studies have also demonstrated that fluvoxamine has virtually no affinity for α1- or α2-adrenergic, β-adrenergic, muscarinic, dopamine D2, histamine H1, GABA-benzodiazepine, opiate, 5-HT1, or 5-HT2 receptors, despite having an affinity for binding to σ1 receptors. The mechanism of action of Florest in obsessive-compulsive disorder is presumed to be linked to its specific serotonin reuptake inhibition in brain neurons. Florest is a potent inhibitor of the serotonin reuptake transporter in preclinical studies, both in-vitro and in vivo. In in-vitro studies, Florest had no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors. Antagonism of some of these receptors is thought to be associated with various sedative, cardiovascular, anticholinergic, and extrapyramidal effects of some psychotropic drugs.
Obsessive-Compulsive Disorder:
Depression:
Gastrointestinal side effects, anorexia with weight loss (increased appetite and weight gain also reported), hypersensitivity reactions including rash, urticaria, angioedema, arthralgia, myalgia, and photosensitivity. Other side effects include dry mouth, nervousness, anxiety, headache, insomnia, sexual dysfunction, palpitations, tachycardia (may also cause bradycardia), rarely postural hypotension, confusion, ataxia, and abnormal liver function tests.
Florest should not be used concurrently with monoamine oxidase inhibitors, warfarin, benzodiazepines, theophylline, aminophylline, tricyclic antidepressants, and alcohol.
Florest should be used with caution in patients with a history of mania, seizures, suicidal tendency, concomitant EOT, cardiac disease, diabetes mellitus, angle-closure glaucoma, history of bleeding disorders, hepatic and renal impairment. Forest may also impair the performance of skilled tasks (driving).
Store below 25°C, in a cool & dry place. Keep away from light. Keep out of the reach of children.
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