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Lubistone 24mcg Soft Gelatin Capsule 1 Strip
Lubistone is used for the treatment of the following conditions:
- Chronic Idiopathic Constipation (CIC): Recommended for adults experiencing long-term constipation with no identifiable cause.
- Opioid-induced constipation (OIC): Prescribed for adults suffering from constipation due to opioid medications.
- Irritable Bowel Syndrome with Constipation (IBS-C): The only FDA-approved medication for treating IBS-C in women aged 18 years and older.
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✅ Description:
Lubiprostone is a chloride channel activator that increases intestinal fluid secretion, promoting bowel movements without affecting sodium and potassium levels in the blood. It activates ClC-2 channels on the intestinal lining, improving stool passage and relieving constipation symptoms.
Additionally, Lubiprostone restores the intestinal mucosal barrier by enhancing tight junction proteins. It acts locally in the intestines; symptom relief is usually observed within 24 hours.
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✔️ Dosage & Administration
- Chronic Idiopathic Constipation (CIC): 24 mcg twice daily with food and water.
- Opioid-induced constipation (OIC): 24 mcg twice daily with food and water.
- Irritable Bowel Syndrome with Constipation (IBS-C): 8 mcg twice daily with food and water.
- Children & Adolescents: Safety and efficacy have not been studied in this group.
- Elderly Patients (>65 years): Effectiveness remains consistent with younger adults.
- Renal Impairment: Not studied in patients with kidney dysfunction.
- Hepatic Impairment: Dose adjustment is required for patients with moderate to severe liver impairment.
(Always take medication as per the advice of a registered physician.)
✔️ Drug Interactions
- Studies suggest a low likelihood of drug interactions.
- Lubiprostone is not metabolized by cytochrome P450 enzymes, reducing the risk of interactions with other medications.
- No significant protein-binding interactions have been identified.
✔️ Contraindications
Not to be used in patients with known or suspected mechanical gastrointestinal obstruction.
✔️ Possible Side Effects
- Common: Nausea, vomiting, loose stools, dry mouth, stomach discomfort, dizziness, headache.
✔️ Pregnancy & Lactation
- Pregnancy Category C: Should only be used during pregnancy if the benefits outweigh the potential risks to the fetus.
- Breastfeeding: It is unknown whether the drug is excreted in human milk.
✔️ Precautions & Warnings
- Nausea: May occur; taking the medication with food may help reduce nausea.
- Diarrhea: Should not be used in patients with severe diarrhea.
- Bowel Obstruction: Before starting treatment, ensure there is no mechanical gastrointestinal obstruction if symptoms suggest one.
✔️ Storage Conditions
- Store in a cool, dry place below 25°C.
- Protect from light.
- Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
