Fedrin 25mg/5ml Injection

✔️ Uses of Fedrin 25mg/5ml Injection

Treatment of hypotension following spinal anesthesia.

✔️ How does Fedrin 25mg/5ml Injection work?

Fedrin acts on blood vessels, improving blood flow to the heart and lungs.

✔️ Side Effects of Fedrin 25mg/5ml Injection

Common side effects include gastrointestinal disorders, cardiac disorders, nervous system disorders, and psychiatric disorders. Potentially fatal effects may occur in cases of hypersensitivity or overdose.

✔️ Quick Suggestions:

• Fedrin is usually given as a slow injection into the veins by a healthcare professional.
• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Inform your doctor if you are taking or have recently taken medication for severe depression.

✔️ Indications of Fedrin 25mg/5ml Injection

Fedrin is indicated to reverse hypotension induced by spinal or epidural anesthesia. It is not effective in hypotensive crises due to shock, circulatory collapse, or hemorrhage.

✔️ Pharmacology:

Ephedrine, the active ingredient in Fedrin, is a stimulant drug classified as a sympathomimetic. It acts as both an alpha and beta-adrenergic agonist and enhances the release of norepinephrine, a potent alpha agonist. Its effects are similar to those of the body's primary adrenergic hormone, adrenaline. Ephedrine increases central nervous system activity and stimulates other target cells.

✔️ Dosage & Administration of Fedrin 25mg/5ml Injection

To reverse hypotension induced by spinal or epidural anesthesia, administer 3 to 6 mg (maximum 9 mg) of Ephedrine Hydrochloride by slow intravenous injection, repeated every 3 to 4 minutes as needed. The maximum total dose is 30 mg. Ephedrine can also be administered intramuscularly or subcutaneously.

• Intravenous preparation must be diluted before administration.
• Fedrin is administered by a healthcare professional through slow injection into the veins. Self-administration is not recommended.

Large doses of Fedrin may cause giddiness, headache, nausea, vomiting, sweating, palpitations, difficulty in micturition, tremors, anxiety, restlessness, and insomnia. Some patients may experience these symptoms even with the usual therapeutic dosage.

✔️ Interaction

Fedrin may cause a hypertensive crisis in patients taking Monoamine Oxidase Inhibitors. Use with caution in patients undergoing anesthesia with cyclopropane, halothane, or other volatile anesthetics. Increased risk of arrhythmias may occur in patients receiving cardiac glycosides, quinidine, or tricyclic antidepressants. There's also an increased risk of vasoconstrictor effects in patients receiving ergot alkaloids or oxytocin.

✔️ Contraindications

Ephedrine is contraindicated in coronary thrombosis and should be used with caution in patients with organic heart disease, hyperthyroidism, hypertension, and angina pectoris. Use caution in patients receiving digitalis.

✔️ Pregnancy & Lactation

Ephedrine is classified as Category C in pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus. Ephedrine is distributed into breast milk, so its use during lactation is not recommended due to the risk of adverse effects in the infant.

✔️ Precautions & Warnings

Use Fedrin with caution in patients with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, or angle-closure glaucoma. It may increase difficulty with micturition in patients with prostatic enlargement. Increased fetal heart rate and adverse effects in breast-fed infants have been reported.

✔️ Storage Conditions:

Store Fedrin in a cool, dry place, protected from light. Keep it out of reach of children.