Palbocent | Palbociclib 125 | 7 Capsules
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Home Medicines Cancer/oncology Palbocent 125 | 7 Capsules | 1 Strip

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Palbocent 125 | 7 Capsules | 1 Strip

Generic: Palbociclib

Type: Capsule

Pack Size: 7pcs

Palbocent is a selective cyclin-dependent kinase (CDK) 4 and 6 inhibitor, used in the management of:

  • Hormone receptor (HR)-positive, HER2-negative advanced or metastatic breast cancer
  • In combination with aromatase inhibitors as first-line endocrine therapy in postmenopausal women

In combination with fulvestrant in women with progression after prior endocrine therapy

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✅ Description:

Palbociclib targets CDK4 and CDK6, enzymes vital to cell cycle progression. These kinases, when bound to cyclin D1, phosphorylate the retinoblastoma (Rb) protein, releasing E2F transcription factors and allowing cells to transition from the G1 phase to the S phase.

By inhibiting CDK4/6, Palbociclib prevents this progression, resulting in cell cycle arrest, particularly in ER-positive breast cancer cells. When used with antiestrogens (like fulvestrant or aromatase inhibitors), this inhibition is enhanced, promoting cellular senescence and reducing tumor proliferation.

Preclinical studies have shown that the combination therapy results in:

  • Stronger inhibition of Rb phosphorylation
  • Reduced E2F signaling
  • Enhanced tumor suppression
  • Sustained growth arrest even after drug withdrawal
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✔️ Common Side Effects
  • Hematologic: Neutropenia, leukopenia, anemia, thrombocytopenia
  • GI & General: Nausea, vomiting, diarrhea, loss of appetite, fatigue
  • Liver Enzymes: Elevated AST/ALT
  • Skin & Mucosa: Rash, dry skin, hair thinning/loss, mouth sores
  • Other: Fever, infections, weakness
✔️ Dosage & Administration

Recommended Dose: 125 mg orally, once daily for 21 consecutive days, followed by 7 days off (28-day cycle)

With food: Always administer with food

Timing: Same time daily is recommended

For men receiving aromatase inhibitors, concurrent use of an LHRH agonist should be considered.

✔️ Dose Modifications (Adverse Reactions)
  • Starting dose: 125 mg/day
  • 1st reduction: 100 mg/day
  • 2nd reduction: 75 mg/day

Discontinue if further reduction is necessary below 75 mg/day

Not indicated for use in children.

✔️ Drug Interactions

Metabolism:

Primarily metabolized by CYP3A and SULT2A1

Increased Palbocent exposure (avoid coadministration):

Strong CYP3A inhibitors: Itraconazole, Ketoconazole, Clarithromycin, Ritonavir, etc.

Grapefruit or grapefruit juice should also be avoided.

If unavoidable, reduce Palbocent dose.

Decreased Palbocent exposure (avoid coadministration):

Strong CYP3A inducers: Rifampin, Phenytoin, Carbamazepine, Enzalutamide, St. John's Wort

Palbocent as an inhibitor:

May increase plasma levels of sensitive CYP3A substrates (e.g., fentanyl, tacrolimus, cyclosporine), requiring dose adjustments.

✔️ Warnings & Precautions

1. Neutropenia

Reported in up to 80% of patients in clinical trials

Grade 3 neutropenia in ~66% of cases

Monitor CBC at baseline, Day 15 of Cycles 1 and 2, then each cycle

Withhold or reduce dose for Grade 3–4 neutropenia

Febrile neutropenia in ~1.8% of patients

2. Interstitial Lung Disease (ILD)/Pneumonitis

Rare but potentially life-threatening

Monitor for new or worsening cough, dyspnea, or hypoxia

Discontinue permanently if severe or confirmed ILD/pneumonitis is diagnosed

3. Embryo-Fetal Toxicity

Teratogenic risk based on animal studies

Advise effective contraception during treatment and for 3 weeks after the last dose

Discontinue treatment if pregnancy occurs

✔️ Pregnancy & Lactation

Pregnancy Category D: Contraindicated in pregnancy due to risk of fetal harm

Lactation: Unknown if excreted in breast milk; breastfeeding is not recommended

✔️ Storage Conditions
  • Store at below 30°C
  • Protect from moisture and light
  • Keep out of reach of children
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Delivery typically takes 1-2 business days, depending on your location.

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Currently, ePharma only delivers within Bangladesh.

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We accept debit/credit cards, Bkash, Nagad, and cash on delivery.

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⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
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