Decomit Inhaler is indicated for the preventive management of asthma in adults and children, including mild, moderate, and severe cases. It contains beclometasone dipropionate, an inhaled corticosteroid that reduces inflammation in the lungs. Compared to systemic corticosteroids, inhaled beclometasone offers effective anti-inflammatory action with fewer and less severe side effects.
Mild asthma: For patients who require regular use of a symptomatic bronchodilator.
Moderate asthma: For patients with unstable or worsening asthma despite prophylactic therapy or bronchodilator alone.
Severe asthma: For patients with chronic severe asthma, including those dependent on systemic corticosteroids. Switching to high-dose inhaled beclometasone may allow a reduction or elimination of oral corticosteroid use.
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Beclometasone dipropionate works by producing anti-inflammatory and vasoconstrictive effects in the lungs. While the exact mechanism of its anti-inflammatory action is not fully understood, corticosteroids are known to influence a wide range of cells and mediators involved in inflammation, including:
Cells: mast cells, eosinophils, neutrophils, macrophages, lymphocytes
Mediators: histamine, eicosanoids, leukotrienes, cytokines
Beclometasone dipropionate is a pro-drug with low glucocorticoid receptor binding. It is metabolized by esterase enzymes into its active form, beclometasone-17-monopropionate (B-17-MP), which has potent topical anti-inflammatory effects. Clinical studies showed no histopathologic changes in the nasal mucosa after intranasal administration.
Decomit Inhaler is for oral inhalation only, and the dose should be tailored to asthma severity and patient response.
Adults (including elderly):
Usual starting dose: 200 micrograms twice daily
Severe cases: 600–800 micrograms per day, divided into 2–4 doses
Dose may be reduced once asthma stabilizes
Children:
50–100 micrograms, 2–4 times daily based on response
Alternative: 100 or 200 micrograms twice daily
Usual starting dose: 100 micrograms twice daily
Decomit 250 Inhaler is not recommended for children
Hepatic or renal impairment: No dose adjustment required.
Correct inhaler use is critical for effectiveness. Improper use reduces medicine delivery to the lungs, decreasing efficacy.
Step-by-step instructions (National Asthma Guidelines):
Cleaning: Once a week, remove the canister, rinse plastic parts in warm water, dry thoroughly, and reassemble. Do not immerse the metal canister.
Hypersensitivity to any component of the inhaler
Special care for patients with active or latent pulmonary tuberculosis
Limited human safety data
Animal studies show possible fetal abnormalities (cleft palate, intrauterine growth retardation)
Breastfeeding mothers: use only if benefits outweigh risks
Instruct patients on proper inhaler technique to ensure effective lung delivery
Use regularly every day, even when asymptomatic, for optimal benefit
Store below 30°C, protected from heat and sunlight
Do not break, puncture, or burn canister, even when empty
Keep away from children and eyes
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.