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Diproxen 500mg Tablet 1 Strip
Diproxen is used to alleviate symptoms and inflammation associated with:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Juvenile arthritis
- Tendonitis
- Bursitis
- Acute gout
It is also effective in managing primary dysmenorrhea and various types of pain.
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✅ Description:
Naproxen, a non-selective NSAID, inhibits both COX-1 and COX-2 enzymes, reducing prostaglandin production. While COX-2 is primarily responsible for inflammation, pain, and fever (and hence the therapeutic effects), COX-1 maintains normal functions like protecting the stomach lining. Inhibition of COX-1 is linked to gastrointestinal and renal side effects.
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✔️ Dosage & Administration of Diproxen 500
Naproxen should be taken with water after meals.
Enteric-Coated Tablets – Adults
- Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis: 500–1000 mg/day in two divided doses (every 12 hours). Max: 1000 mg/day.
- Acute gout: 750 mg initially, then 250 mg every 8 hours until symptoms resolve.
- Dysmenorrhea: 500 mg initially, then 250 mg every 6–8 hours as needed (up to 5 days).
- Pain/musculoskeletal disorders: 500 mg initially, followed by 250 mg at 6–8 hour intervals.
- Children under 16 years: Not recommended for tablets.
✔️ Drug Interactions
- ACE inhibitors: Reduced antihypertensive effect.
- Antacids/Sucralfate: Delay absorption.
- Aspirin/Warfarin/SSRIs: Increased risk of GI bleeding.
- Diuretics: Decreased natriuretic effect.
- Methotrexate: Heightened toxicity risk.
✔️ Contraindications
- Known hypersensitivity to Naproxen.
- History of asthma or allergic reactions to NSAIDs or aspirin.
- Use in post-CABG surgery pain is contraindicated.
✔️ Side Effects of Diproxen 500
- GI: Nausea, indigestion, abdominal pain, diarrhea.
- CNS: Headache, dizziness, drowsiness.
- Skin: Rash, itching, purpura.
- Cardiovascular: Edema, palpitations.
- Other: Vision and hearing disturbances.
✔️ Use in Pregnancy & Lactation
- May negatively impact fetal development, particularly in the third trimester. Use during the first and third trimesters should be carefully assessed.
- Though small amounts pass into breast milk, some sources advise against use during breastfeeding.
✔️ Precautions & Warnings
- Renal: Monitor kidney function in patients with impaired renal health. Risk of nephropathy, including nephrotic syndrome and interstitial nephritis.
- Hepatic: Cases of jaundice have been reported.
- Cardiovascular/GI Risk: Use with caution in those prone to GI bleeding or CV conditions.
✔️ Storage:
Store below 30°C, protected from moisture and light. Keep out of children’s reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
