Fexo 60mg Tablet

✔️ Uses of Fexo 60mg Tablet

• Allergic Rhinitis
• Chronic Urticaria

✔️ How does Fexo 60mg Tablet work?

Fexo 60mg Tablet contains Fexofenadine which works by blocking the release of a chemical substance called histamine from your body. This helps in reducing the symptoms of allergic hives and nasal congestion.

✔️ Side Effects of Fexo 60mg Tablet

• Vomiting
• Headache
• Coughing
• Diarrhea
• Painful menstruation
• Pain in the arms and legs
• Swelling of face, lips, eyelids, tongue, hands and feet
• Difficulty in breathing
• Dizziness
• Drowsiness

✔️ Quick Suggestions:

• Avoid drinking fruit juices like apple or orange as they may affect the absorption of Fexo 60mg Tablet and potentially increase the risk of side effects.
• Stick to simple meals and avoid consuming rich or spicy foods while taking this medicine to reduce the risk of nausea or digestive discomfort.
• Do not use antacids within 30 minutes before or after taking Fexo 60mg Tablet, as they can interfere with the absorption of the medicine. It is recommended to take antacids at least 2 hours apart from this medication.
• Fexo 60mg Tablet is specifically indicated for the relief of symptoms of allergic rhinitides, such as sneezing, watery eyes, and a runny or blocked nose. Do not use this medicine for any other condition unless prescribed by your doctor.
• Take Fexo 60mg Tablet exactly as prescribed by your doctor or healthcare professional. Do not exceed the recommended dose or take it for a longer duration than advised.
• Before starting Fexo 60mg Tablet, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. It is important to discuss the potential risks and benefits of using this medication during pregnancy or while breastfeeding.
• Inform your doctor about all other medications you are taking, including prescription drugs, over-the-counter medicines, and any herbal supplements. This will help your doctor identify any potential drug interactions.
• If you have a history of heart or blood vessel-related disorders or experience any concerning side effects after taking Fexo 60mg Tablet, notify your doctor immediately.
• Common side effects of Fexo 60mg Tablet may include nausea, headache, sleepiness, and dizziness. If these side effects persist or worsen, even after completing the course of the medicine, consult your doctor for further evaluation.
• If you experience dizziness or sleepiness after taking Fexo 60mg Tablet, avoid activities that require mental alertness, such as driving or operating heavy machinery.

✔️ Indication of Fexo 60mg Tablet

Fexofenadine Hydrochloride is used in adults and children (aged above 12 years) to provide relief from the symptoms of

• Hay Fever (Seasonal Allergic Rhinitis)
• Chronic Idiopathic Urticaria

✔️ Pharmacology

Fexofenadine hydrochloride is an antihistamine medication that primarily acts as a selective peripheral H1 receptor antagonist. Here are some important points regarding its pharmacokinetics:

• After oral administration, fexofenadine is rapidly absorbed, and peak plasma concentrations are reached within 2-3 hours.
• Approximately 60-70% of fexofenadine is bound to plasma proteins.
• Metabolism of fexofenadine occurs to a limited extent, with about 50% of the total dose being metabolized. This metabolism primarily takes place in the intestinal mucosa, while only 0.5% to 1.5% of the dose undergoes hepatic biotransformation mediated by the cytochrome P450 system.
• The elimination half-life of fexofenadine is reported to be around 14 hours. However, in individuals with renal impairment, the half-life may be prolonged.
• Fexofenadine is primarily excreted in the feces, with only a small amount (approximately 10%) excreted in the urine.
• It is worth noting that fexofenadine does not readily cross the blood-brain barrier, which contributes to its selective peripheral H1 receptor antagonism and helps minimize sedation and other central nervous system side effects.

These pharmacokinetic properties provide insights into the absorption, distribution, metabolism, and excretion of fexofenadine in the body.

✔️ Dosage & Administration of Fexo 60mg Tablet

For the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria, the recommended dosages of fexofenadine for different age groups and renal function status are as follows:

Seasonal Allergic Rhinitis:

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily

Children from 2 to 11 years:

• Suspension: 30 mg or 5 ml twice daily
• In case of impaired renal function: 30 mg or 5 ml once daily

Chronic Idiopathic Urticaria:

Adults and children 12 years and older:

• Tablet: 60 mg twice daily or 120 mg once daily or 180 mg once daily
• In case of impaired renal function: 60 mg once daily

Children from 6 to 11 years:

• Tablet: 30 mg twice daily or 60 mg once daily
• In case of impaired renal function: 30 mg once daily

Children from 6 months to less than 2 years:

• Suspension: 15 mg or 2.5 ml (1/2 tsp) twice daily
• In case of impaired renal function: 15 mg or 2.5 ml (1/2 tsp) once daily

Children from 2 to 11 years:

• Suspension: 30 mg or 5 ml (1 tsp) twice daily
• In case of impaired renal function: 30 mg or 5 ml (1 tsp) once daily

These dosage recommendations may vary depending on individual patient factors and should be determined by a healthcare professional. It's important to follow the prescribed dosage and consult a doctor or pharmacist for appropriate dosing instructions based on specific circumstances.

✔️ Interaction

• Some medicines can affect the way Fexo 60mg Tablet works or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Co-administration of fexofenadine with ketoconazole or erythromycin may increase the plasma levels of fexofenadine. This can potentially lead to an increased risk of adverse effects. It is recommended to use caution and consider dose adjustments or alternative medications in such cases. Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction.
• Acidity medicines should be taken two hours before this medicine and not along with it.
• In cases of renal impairment, the dosage of fexofenadine may need to be adjusted. It is important to consult a healthcare professional for appropriate dosage recommendations based on the severity of renal impairment.
• For pregnancy and lactation, fexofenadine should be used with caution. The excretion of fexofenadine in breast milk is unknown, but according to the American Academy of Pediatrics (AAP), it is considered "compatible with nursing." It is advised to consult a healthcare professional before using fexofenadine during pregnancy or while breastfeeding to assess the potential risks and benefits.
• Fexofenadine is not recommended for use in children under 6 years of age. For children between 6 and 11 years, the recommended dosage and administration should be determined by a healthcare professional.
• It's important to follow the guidance of a healthcare professional and the product label for the safe and appropriate use of fexofenadine in these specific situations.
• Fexofenadine may also increase the adverse effects of other anticholinergic medications and CNS depressants. Concurrent use should be done with caution, and it may be necessary to adjust the dosages or consider alternative medications.
• There is a potential for increased arrhythmogenic effects when fexofenadine is used concurrently with antipsychotic agents such as phenothiazines. It is advised to avoid concurrent usage of these medications.
• The efficacy of betahistine, a medication used for the treatment of vertigo and Meniere's disease, may be reduced when used concurrently with fexofenadine. Close monitoring and adjustment of the betahistine dosage may be necessary in such cases.
• Pramlintide, a medication used for diabetes management, may increase the anticholinergic effects of fexofenadine. It is important to monitor for increased anticholinergic side effects and adjust the dosage of fexofenadine if needed.
• The bioavailability of fexofenadine may be increased by verapamil, a calcium channel blocker. Close monitoring for increased fexofenadine effects or adverse reactions is advised when using these medications together.
• The efficacy of fexofenadine may be reduced by rifampin, an antibiotic. It is recommended to monitor for decreased effectiveness of fexofenadine when used concurrently with rifampin and consider alternative treatment options if necessary.
• It is important to consult with a healthcare professional or pharmacist before combining medications to ensure their safe and effective use. They can provide specific guidance based on the individual's medical history and current medication regimen.

✔️ Contraindications

Fexofenadine is contraindicated in patients with known hypersensitivity to any of the ingredients.

✔️ Pregnancy & Lactation

Fexofenadine Hydrochloride is classified as pregnancy category C by the US Food and Drug Administration. So, unless the potential advantages to the other outweigh the potential dangers to the fetus, Fexofenadine Hydrochloride should be avoided during pregnancy and breastfeeding.

✔️ Precautions & Warnings

• In cases of renal impairment, the dosage of fexofenadine may need to be adjusted. It is important to consult a healthcare professional for appropriate dosage recommendations based on the severity of renal impairment.
• For pregnancy and lactation, fexofenadine should be used with caution. The excretion of fexofenadine in breast milk is unknown, but according to the American Academy of Pediatrics (AAP), it is considered "compatible with nursing." It is advised to consult a healthcare professional before using fexofenadine during pregnancy or while breastfeeding to assess the potential risks and benefits.
• Fexofenadine is not recommended for use in children under 6 years of age. For children between 6 and 11 years, the recommended dosage and administration should be determined by a healthcare professional.
• It's important to follow the guidance of a healthcare professional and the product label for the safe and appropriate use of fexofenadine in these specific situations.

✔️ Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach.