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Iso Trin 20 belongs to a group of medicines called retinoids, used to treat severe acne. Take it as advised by your doctor, and it may take several weeks for symptoms to improve.
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✅ Description:
Isotretinoin: Oral retinoid for severe nodular acne
Treatment of severe nodular acne characterized by large, inflamed, and painful lesions deep under the skin
Reduces sebum production in skin glands, decreasing the occurrence of acne or pimples. Exhibits anti-inflammatory action, reducing redness and swelling associated with acne.
- Take it with food.
- Complete the entire treatment course, even if symptoms improve.
- Implement skin protection measures like sunscreen and maintain a balanced diet during treatment.
- Allergic reaction to the medication.
- Not recommended during pregnancy and breastfeeding.
- Not for use in children under 12 years of age.
- Inform your doctor of liver problems before use.
- Avoid prolonged exposure to harsh sunlight; use sunscreen.
- Refrain from alcohol consumption during treatment.
- Contact your doctor promptly if you experience serious side effects such as changes in mood or depression, dizziness, ringing in ears, headache, vision problems, eye pain, increased thirst, or increased urination while using this medicine.
Safety Advices
Alcohol
UNSAFE
When consuming alcohol with Iso Trin 20, caution is advised. It is recommended to consult your doctor regarding alcohol consumption.
Pregnancy
UNSAFE
Iso Trin 20 is highly unsafe to use during pregnancy. Studies on pregnant women and animals have shown significant harmful effects on the developing baby. Seeking your doctor's advice is crucial.
Breastfeeding
UNSAFE
Iso Trin 20 is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into breast milk and harm the baby. Consult your doctor before using it while breastfeeding.
Driving
Iso Trin 20 may cause side effects that could affect your ability to drive. Night vision may worsen during treatment, and instances of drowsiness and dizziness have been reported rarely, impacting driving ability.
Kidney
CONSULT YOUR DOCTOR
Iso Trin 20 is probably safe to use in patients with kidney disease. Limited data suggests that dose adjustment may not be needed in these patients. Consult your doctor if you experience excessive tiredness, puffy eyes, or difficulty in urination.
Liver
CONSULT YOUR DOCTOR
Iso Trin 20 is probably unsafe to use in patients with liver disease and should be avoided. Consult your doctor regarding its use if you have liver-related concerns.
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✔️ Uses of Iso Trin 20mg Capsule
Acne
✔️ How does Iso Trin 20mg Capsule work?
Reduces sebaceous gland size and sebum production.
✔️ Side Effects of Iso Trin 20mg Capsule
- Common: Dry skin.
- Potentially Fatal: Anaphylaxis, hemorrhagic pancreatitis.
✔️ Quick Suggestions:
- Take it with food.
- Avoid sun exposure; use protective measures.
- Avoid face waxing and laser treatment.
- Do not take if pregnant, planning pregnancy, or breastfeeding.
- May cause dryness; drink plenty of water, and use moisturizer.
✔️ Indication of Iso Trin 20mg Capsule
Isotretinoin is indicated for the treatment of severe recalcitrant nodular acne, where nodules are inflammatory lesions with a diameter of 5 mm or greater. It should be reserved for patients unresponsive to conventional therapy, including systemic antibiotics. Female patients must not be pregnant due to the risk of severe birth defects. A single course of therapy for 15 to 20 weeks can result in complete and prolonged remission. If a second course is needed, it should be initiated at least 8 weeks after the first course.
✔️ Pharmacology
Isotretinoin, a synthetic retinoid, reduces sebaceous gland size, inhibits sebum production, and regulates cell proliferation and differentiation. It also exhibits dermal anti-inflammatory effects.
✔️ Dosage & Administration of Iso Trin 20mg Capsule
- Adult Dose: Oral, 0.5-1 mg/kg/day for severe acne.
- Child Dose: <12 years: Safety not established; >12 years: 0.5-1 mg/kg/day.
- Renal Dose: Reduce dose in severe impairment.
✔️ Interaction
- Additive toxicity with vitamin A.
- Decreased efficacy with microdosed progesterone.
- Increased risk of bone loss with phenytoin.
- Reduces plasma levels of carbamazepine.
- Potentially Fatal: Increased risk of pseudotumor cerebri with tetracyclines.
✔️ Contraindications
Pregnancy, lactation.
✔️ Pregnancy & Lactation
Category X: Contraindicated in women who are or may become pregnant.
✔️ Precautions & Warnings
- Monitor blood lipids and liver function.
- Monitor blood glucose in known or suspected diabetes patients.
- Genetic predisposition for osteoporosis, psychiatric history.
- Avoid prolonged sun exposure and certain procedures during treatment.
- Discontinue if severe adverse effects occur.
✔️ Storage Conditions
Store between 20-25°C. Protect from light.
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