Clasrin 1% Cream 10gm

✔️ Uses of Clasrin Cream

• Treatment of Acne

✔️ Side Effects of Clasrin Cream

• Dry skin
• Skin irritation
• Diarrhea
• Gastrointestinal disturbance

✔️ How Does Clasrin Cream work?

Clasrin Cream is an antibiotic that works by stopping the growth of bacteria causing acne on your skin

✔️ Missed Dose of Clasrin Cream

If you miss a dose of Clearacne 1% Cream, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule.

✔️ Quick Suggestions:

• You have been prescribed Clasrin Cream for the treatment of acne.
• You may have to use it for a long time before your acne starts to improve. Be patient and keep using it every day.
• Wash your skin with a mild cleanser and pat it dry before applying Clasrin Cream.
• Apply it as a thin layer onto clean, dry, unbroken skin affected by acne.
• It may cause minor burning, stinging, or irritation when applied. Inform your doctor if this does not go away.
• Avoid contact with your eyes, nose, or mouth. Rinse it off with water if you accidentally get the cream in these areas.
• If you think the area of skin you are treating has become more irritated and infected, you should stop using Clasrin Cream and consult your doctor.

✔️ Indication of Clasrin Cream

Clasrin Cream is an antibiotic that works by stopping the growth of bacteria causing acne on your skin

✔️ Pharmacology

Clascoterone (cortexolone 17 α-propionate) is a novel androgen receptor antagonist that works by binding competitively to androgen receptors. By blocking androgen signaling, clascoterone inhibits acne-promoting processes like sebaceous gland proliferation, excess oil production, and inflammatory pathways.
Acne vulgaris is a multifaceted skin condition marked by increased sebum production, hyperkeratinization, bacterial overgrowth, and inflammation. Androgens, specifically testosterone and dihydrotestosterone (DHT), are implicated in acne development by binding to androgen receptors and promoting sebum production and inflammatory cytokines. Clascoterone blocks these actions by inhibiting androgen receptor activity, thus reducing acne symptoms.
Androgenetic alopecia, a genetic, androgen-dependent condition, involves DHT binding to androgen receptors in scalp cells, triggering gene transcription that leads to hair loss. Clascoterone interferes with this process by blocking DHT-receptor binding, decreasing DHT-induced IL-6 synthesis.

✔️ Dosage & Administration of Clasrin Cream

Gently clean the affected area, then apply a thin layer (about 1 gram) of Clasrin cream twice daily, in the morning and evening, to the affected skin. Avoid accidental transfer to the eyes, mouth, or mucous membranes. If accidental contact occurs, rinse thoroughly with water or as instructed by a physician.
For Children and Adolescents: Clasrin cream's safety and effectiveness for treating acne vulgaris have not been established for children under 12 years.

✔️ Interaction

No clinical studies have evaluated Clasrin cream's potential drug interactions.

✔️ Contraindications

No specific contraindication data for clascoterone cream is available.

✔️ Pregnancy & Lactation

There is insufficient data on clascoterone cream usage during pregnancy to determine any risk for birth defects, miscarriage, or negative maternal or fetal outcomes. Information regarding clascoterone presence in breast milk, its impact on milk production, or its effects on breastfed infants is also unavailable.

✔️ Precautions & Warnings

• Local Irritation: Clasrin cream may cause itching, burning, redness, or peeling. Reduce application frequency or discontinue if these occur.
• HPA Axis Suppression: Clasrin may affect the hypothalamic-pituitary-adrenal axis during or post-treatment.
• Pediatric Sensitivity: Children may be more prone to systemic side effects.
• Hyperkalemia: Elevated potassium levels were noted in some participants during trials.

✔️ Storage:

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.