Nulevi 1% Cream 15gm Tube

✔️ Uses: Nulevi 1% Cream

Acne

✔️ How does Nulevi 1% Cream work?

Nulevi contains clascoterone which works by inhibiting bacterial protein synthesis, which inhibits bacterial growth. It shows a bacteriostatic effect, which stops bacterial reproduction but doesn't kill them.

✔️ Side Effects of Nulevi 1% Cream

• Burning sensation
• Itching
• Dryness
• Redness
• Oily skin
• Peeling of the skin

✔️ Quick Suggestions:

• Consult your dermatologist if you do not notice any improvement after 4-6 weeks of treatment with Nulevi 1% Cream.
• Foam products are flammable; keep them away from flames and extreme heat. Do not puncture or incinerate the foam canister.
• If the acne doesn't improve, an ultrasound scan of the abdomen is advised to check if there is any possibility of PCOD (Polycystic Ovarian Disease).

✔️ Indications: Nulevi 1% Cream

Clascoterone is an androgen receptor antagonist used for the topical treatment of acne vulgaris in patients 12 years of age and older. This medicine is available only with your doctor's prescription.

✔️ Dosage of Nulevi 1% Cream

• For Topical dosage form (cream):
  • For acne:
    • Adults and children 12 years of age and older—Apply a thin layer to the affected area(s) of the skin 2 times a day, in the morning and the evening.
    • Children younger than 12 years of age—Use and dose must be determined by your doctor.

✔️ How to use Nulevi 1% Cream

To apply Clascoterone cream, gently cleanse the affected area and ensure it is dry. Apply a thin layer to the affected skin twice daily, once in the morning and once in the evening. Be cautious not to let the cream contact your eyes, mouth, or other mucous membranes; if it does, rinse thoroughly with water. This cream is intended for topical use only, and it should not be used in the eyes, mouth, or vaginal area.

✔️ Pediatric Use: Nulevi 1% Cream

Clascoterone’s safety and efficacy are established in patients aged 12-18 through clinical trials and pharmacokinetic studies. It is not recommended for children under 12 due to insufficient data.

✔️ Geriatric Use: Nulevi 1% Cream

Clascoterone was not specifically studied in patients over 65, so dose selection should start cautiously, taking into account potentially reduced liver, kidney, or heart function common with aging.

✔️ Interaction

No clinical study evaluating the drug interaction of Nulevi cream has been conducted.

✔️ Contraindications

Data on the contraindication of clascoterone cream is not available.

✔️ Pregnancy & Lactation: Clascoterone

Pregnancy: There is no clinical data on the effects of Clascoterone cream in pregnant women, so potential risks to the fetus are unknown. Animal studies indicate that when clascoterone is administered at higher doses than the maximum human dose, there are increased malformations and pregnancy loss in animals. The background risk of birth defects and miscarriage for acne patients is unknown, though for the general U.S. population, these risks are estimated at 2-4% and 15-20%, respectively.
Lactation: There is no information on whether clascoterone or its metabolites are excreted in human breast milk or on its effects on a breastfeeding infant or milk production. The potential benefits of breastfeeding should be considered alongside the mother’s treatment needs and possible risks to the infant.

✔️ Precautions & Warnings

Local Skin Reactions: Clascoterone may cause local skin irritation, such as redness, itching, dryness, and scaling. Using other potentially irritating topical products, including harsh soaps, alcohol-based cosmetics, or astringents, should be minimized. Avoid applying to broken, cut, or sunburned skin.
HPA Axis Suppression: Clascoterone may suppress the hypothalamic-pituitary-adrenal (HPA) axis, particularly when used on large areas of skin, for prolonged periods, or with occlusive dressings. If HPA suppression occurs, discontinue use gradually. Pediatric patients may have a higher risk of systemic side effects.

✔️ Storage:

Store below 30°C, away from light and moisture, and keep out of reach of children. Do not keep outdated medicine or medicine no longer needed.