Sixtin 2.5mg Tablet

✔️ Uses of Sixtin 2.5mg Tablet

• Treatment of Type 2 diabetes mellitus

✔️ How does Sixtin 2.5mg Tablet work?

Sixtin 2.5mg Tablet works by inhibiting Dipeptidyl Peptidaye-4 (DPP-4) enzyme activity and decreasing glucagon concentrations, thus increasing glucose-dependent insulin secretion from pancreatic beta cells.

✔️ Side Effects of Sixtin 2.5mg Tablet

• Common side effects include headache, nasopharyngitis, urinary tract infection, hypoglycemia (with insulin or sulfonylurea), and upper respiratory tract infection.

✔️ Quick Suggestions:

• Take Saxagliptin at the same time every day.
• Consistent timing helps establish a routine, making it easier to remember.
• Saxagliptin may have an impact on alertness or coordination.
• Saxagliptin may cause hypoglycemia, especially when:
  • Used with other antidiabetic medicines.
  • Consuming alcohol.
  • Delaying or missing a meal.
• Carry sugary food or fruit juice to address hypoglycemia symptoms.
• Inform your doctor if you experience joint pains or symptoms like stomach pain, nausea, and/or vomiting.
• Timely reporting allows for monitoring and adjustment of the treatment plan if necessary.

✔️ Indications:

• Sixtin is used to treat type 2 diabetes mellitus.
• It is employed alongside a healthy diet and regular exercise to control blood sugar levels.
• Helps prevent serious complications of diabetes like kidney damage and blindness.

✔️ Pharmacology

• Saxagliptin inhibits dipeptidyl peptidase IV (DPP-IV), increasing active incretin levels.
• Raises glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), stimulating insulin production.
• Improves glycemic management in type 2 diabetes.

✔️ Dosage & Administration of Sixtin 2.5mg Tablet

• Recommended dosage: 2.5 mg or 5 mg once daily, regardless of meals.
• No dosage adjustment for mild renal impairment (CrCl >50 mL/min).
• For moderate or severe renal impairment or end-stage renal disease (CrCl ≤ 50 mL/min), the dosage is 2.5 mg once daily.
• Dosage may need adjustment with concomitant use of strong CYP3A4/5 inhibitors.
• Should be taken at the same time every day.
• Be cautious while driving or operating machinery.
• May cause hypoglycemia; carry sugary food in case of low blood sugar symptoms.
• Inform the doctor if joint pains or other symptoms occur.

✔️ Interaction

• Strong CYP3A4/5 inhibitors can interact.
• Interacts with antacids, corticosteroids, opioid pain killers, blood thinners, cholesterol-lowering medicines, anti-allergic drugs, and antianxiety drugs.
• Interaction with grapefruit juice and marijuana can affect the medication's effectiveness.

✔️ Contraindications

Diabetic ketoacidosis (a complication of type 1 diabetes).

✔️ Pregnancy & Lactation

Category B: No risk to the fetus shown in animal studies, but no controlled studies in pregnant women.

✔️ Precautions & Warnings

• Allergies, pregnancy, heart failure, and liver issues are highlighted.
• Symptoms of hypersensitivity reactions and pancreatitis should be monitored.
• Use with caution in renal impairment.
• Exercise caution during pregnancy and lactation.

✔️ Storage Conditions

Store between 20-25° C.