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Evania M 5/500mg Tablet
Evania M 5/500mg Tablet
Empagliflozin:
- An SGLT2 (Sodium-Glucose Co-Transporter 2) inhibitor.
- Reduces glucose reabsorption in the kidneys, increases urinary glucose excretion, and lowers blood glucose levels.
Metformin Hydrochloride:
- A biguanide antihyperglycemic agent.
- Reduces basal and postprandial glucose levels by decreasing hepatic glucose production, improving insulin sensitivity, and increasing peripheral glucose utilization.
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✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Evania-M Tablet is indicated for the treatment of adults with type 2 diabetes mellitus as an adjunct to diet and exercise in the following situations:
- Inadequate control on Metformin alone: For patients not sufficiently controlled on their maximally tolerated dose of Metformin.
- Combination therapy: In combination with other antidiabetic medications in patients not controlled with Metformin and these medications.
- Pre-existing combination therapy: For patients already on Empagliflozin and Metformin as separate tablets.
✔️ Side Effects
Empagliflozin:
- Common: Urinary tract infections, genital mycotic infections, thirst, increased urination.
- Rare: Diabetic ketoacidosis, Fournier’s gangrene.
Metformin:
- Very common: Gastrointestinal disturbances, hypoglycemia (with sulfonylureas or insulin).
- Rare: Lactic acidosis, vitamin B12 deficiency.
✔️ Dosage & Administration
- Individualized dosage: Based on patient response and tolerability.
- Administration: Take twice daily with meals. Gradual dose escalation is recommended to minimize gastrointestinal side effects.
Maximum daily doses:
- Metformin Hydrochloride: 2000 mg.
- Empagliflozin: 25 mg.
- Switching from Metformin alone: Start with Empagliflozin 5 mg and a similar total daily dose of Metformin.
- Switching from Empagliflozin alone: Start with Metformin Hydrochloride 500 mg and a similar total daily dose of Empagliflozin.
- Current combination therapy: Use the same total daily doses of Empagliflozin and Metformin as in existing therapy.
- Volume-depleted patients: Correct dehydration before initiating therapy.
- Renal impairment: Contraindicated in patients with an eGFR <45 mL/min/1.73 m².
- Pediatric patients: Not recommended for patients under 18 years.
✔️ Interaction
- Diuretics: May increase volume depletion risks.
- Insulin or insulin secretagogues: Increased risk of hypoglycemia.
- Drugs reducing Metformin clearance (e.g., ranolazine, cimetidine): Increased risk of lactic acidosis.
- Alcohol: Potentiates the effect of Metformin on lactate metabolism. Avoid excessive alcohol consumption.
✔️ Contraindications
- Hypersensitivity to Empagliflozin or Metformin.
- Acute metabolic acidosis (e.g., lactic acidosis, diabetic ketoacidosis).
- Severe renal failure (GFR <30 mL/min).
- Acute conditions affecting renal function (e.g., dehydration, severe infection, shock).
- Hepatic impairment or alcohol abuse.
✔️ Pregnancy & Lactation
- Pregnancy: Potential risks to the fetus during the second and third trimesters. Use only if benefits outweigh risks.
- Lactation: Not recommended as it is unclear if the components are excreted in breast milk.
✔️ Precautions & Warnings
- Lactic acidosis: Rare but serious. Immediate discontinuation and hospital treatment are required if suspected.
- Hypotension: Monitor for symptoms, especially in elderly or volume-depleted patients.
- Ketoacidosis: Evaluate patients with metabolic acidosis symptoms promptly.
- Renal function: Monitor regularly; discontinue if acute kidney injury occurs.
- Infections: Increased risk of urinary and genital infections. Treat promptly if symptoms occur.
- Vitamin B12 deficiency: Monitor annually.
✔️ Storage:
- Store below 30°C.
- Protect from light and moisture.
- Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
