Dosage: Prophylaxis of surgical infection in patients undergoing prostate surgery:

• Adult: 1 g at induction of anaesth repeated if necessary upon removal of catheter. It is given as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Elderly: >80 yr Max: 3 g daily.

Pseudomonal lung infections in cystic fibrosis:

• Adult: 100-150 mg/kg 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min. Max: 9 g daily.
• Child: <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily

Bone and joint infections, Complicated intra-abdominal infections, Skin and skin structure infections, complicated:

• Adult: 1-2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Bacterial meningitis, Empiric therapy for febrile neutropenic patients, Nosocomial pneumonia:

• Adult: 2 g 8 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Complicated urinary tract infections:

• Adult: 1-2 g 8-12 hrly as deep IM inj, slow IV inj over 3-5 min or IV infusion for up to 30 min.
• Child: <40 kg: 100-150 mg/kg daily in 3 divided doses. Max: 6 g daily.
• Elderly: >80 yr Max: 3 g daily.

Side effects: The most common side-effects are local reactions following IV injection and allergic and gastrointestinal reactions. Hypersensitivity reactions are pruritus, rash, and fever. Angioedema and anaphylaxis have been reported very rarely. Gastrointestinal symptoms are diarrhea, nausea, vomiting, and abdominal pain. Central nervous system reactions included headache, dizziness, and paresthesia.