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Defera (Deferiprone) \ Oral Iron Chelator for Thalassemia-related Iron Overload
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Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
Defera is used to manage chronic iron overload in patients with thalassemia major when deferoxamine is inadequate or not tolerated. Treatment should be supervised by a physician experienced in managing iron overload conditions.
Deferiprone is an oral iron chelator with high selectivity for ferric iron (Fe³⁺). It forms stable 3:1 (Deferiprone:Iron) complexes that are efficiently excreted, reducing excess body iron. It shows lower affinity for other metal ions like copper, zinc, and aluminum.
✔️ Side Effects
Gastrointestinal discomfort: nausea, vomiting, diarrhea, abdominal pain
Reddish-brown urine discoloration (harmless)
Other possible effects:
- Joint pain (arthralgia)
- Elevated liver enzymes
- Neutropenia and agranulocytosis – requires weekly neutrophil count monitoring
✔️ Dosage & Administration
Adults & children >6 years: 25 mg/kg three times daily (total max: 100 mg/kg/day)
Dosing must be individualized and supervised by a physician
Take orally, with or without food
Avoid doses exceeding the recommended maximum
✔️ Interactions
Caution with Vitamin C: May increase risk of adverse effects (as seen with deferoxamine)
Avoid use with aluminum-containing antacids
✔️ Contraindications
Known hypersensitivity to deferiprone or any component of the formulation
✔️ Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding due to potential fetal or infant risk.
✔️ Precautions & Warnings
Monitor complete blood count (especially neutrophils) weekly
Use with caution in patients with hepatic or renal impairment
✔️ Storage
Store below 30°C, away from moisture and light.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
