Folate is a water-soluble B vitamin that serves as a coenzyme in DNA and RNA synthesis and amino acid metabolism. During pregnancy, a deficiency can result in serious fetal abnormalities like neural tube defects (NTDs), including spina bifida and anencephaly. Adequate folate levels are essential to reduce risks of preterm birth, low birth weight, and intrauterine growth restriction. Supplementation, especially prior to conception and in early pregnancy, effectively reduces NTD recurrence.
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Folate (6S-5-methyltetrahydrofolate) | Folate is recommended in a variety of conditions, including:
Generally well tolerated, but it's advisable to consult a physician before initiating therapy.
Take 1 to 2 capsules daily or as advised by a healthcare provider.
Phenytoin’s efficacy may be reduced when taken with folic acid.
Folate depletion can result from renal dialysis, certain anticonvulsants, alcohol abuse, and drugs like methotrexate, pyrimethamine, and nitrofurantoin.
Concurrent use with amiodarone may heighten the risk of photosensitivity.
Folate may also accelerate the breakdown of phenobarbital, reducing its effectiveness.
Not recommended for individuals with known hypersensitivity to any component of the formulation.
Folate is safe during pregnancy and compatible with breastfeeding. Supplementation may be necessary in lactating mothers with inadequate dietary intake to prevent megaloblastic anemia.
Store below 25°C, in a dry place away from direct light. Keep out of reach of children.
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