Carica papaya, belonging to the plant family Caricaceae, is an economically important fruit crop worldwide. Many scientific works have been carried out to evaluate the benefits of different parts of the papaya plant, including fruits, seeds, leaves, rind, shoots, roots, or latex. The leaf is considered non-toxic, as its lethal dose is >15 g/kg body weight.
Preclinical studies in mice demonstrated encouraging activity of Carica papaya powder in increasing platelet count. A recent in vitro study showed that Carica papaya leaf extract exhibited significant inhibition of hemolysis, probably due to its membrane-stabilizing potency.
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It has been found to increase the bioavailability of amiodarone, and therefore the dose should be adjusted accordingly when co-administered with Plategen. An in vitro study demonstrated that the action of various antibiotics like penicillin G, ampicillin, amoxicillin-clavulanate, cephalothin, polymyxin B, rifampicin, amikacin, nalidixic acid, gentamycin, chloramphenicol, and ofloxacin was potentiated when co-administered with C. papaya. The extract of C. papaya with antimicrobial agents possesses synergistic properties that act against pathogenic organisms.
Adults: The recommended dose is 250 mg 1-2 capsules daily 2-3 times a day for 5-12 days.
For children more than 1 year and less than 5 years: 1 teaspoonful (5ml) three times a day for 5 days
For children more than 5 years and less than 18 years: 2 teaspoonfuls (10ml) three times a day for 5 days
Above 18 years & above: 3 teaspoonful (15 ml) three times a day for 5 days or as directed by a physician
No health hazards or side effects are known in conjunction with the proper administration of designated therapeutic dosages.
Hypersensitivity, Pregnancy. In males with prostate dysfunction, such as BPH or prostate cancer, Carica
papaya should be avoided as it increases iron absorption. Excess iron may increase oxidative stress, especially in the aging male. Iron overload may increase the risk of developing prostate cancer.
Should be used with caution in individuals with bleeding disorders or those taking blood-thinning medications such as aspirin or warfarin. Co-administration of Plategen papaya extracts with oral hypoglycemic agents may lead to very low blood glucose, as observed in one experimental animal study. Thus, it is important to closely monitor blood glucose levels regularly to avoid hypoglycemia.
Keep away from direct sunlight & moisture. Keep below 30°C in a cool & dry place. Keep the medicine out of reach of children.
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