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Ondansetron: A potent, highly selective 5HT3 receptor antagonist used to control nausea and vomiting.
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✅ Description:
Chemotherapy-Induced Nausea and Vomiting (CINV)
Chemotherapy-induced nausea and vomiting (CINV) is a common side effect of cancer treatment. It can be severe and distressing, significantly affecting the patient's quality of life and treatment compliance. Ondansetron, a 5HT3 receptor antagonist, is used to treat nausea and vomiting caused by chemotherapy. It works by blocking serotonin, a natural substance that causes nausea and vomiting.
Postoperative Nausea and Vomiting (PONV)
Postoperative nausea and vomiting (PONV) occur immediately after surgery and can continue for a day or two. This condition can be triggered by medications like anesthetics used during surgery. Ondansetron is effective in treating PONV by blocking the action of serotonin in the brain, thereby reducing nausea and vomiting.
Radiation-Induced Nausea and Vomiting (RINV)
Radiation-induced nausea and vomiting (RINV) is a common side effect for cancer patients undergoing radiotherapy. Patients may feel sick during or for a short time after radiotherapy treatment. Ondansetron is used to manage RINV by preventing the action of serotonin, thus alleviating nausea and vomiting during radiotherapy sessions.
Safety Advices
Alcohol
UNSAFE
Consuming alcohol with Zofra ODT 8 does not cause any harmful side effects.
Pregnancy
CONSULT YOUR DOCTOR
Zofra ODT 8 is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects on the
Breastfeeding
CONSULT YOUR DOCTOR
Zofra ODT 8 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Driving
SAFE
Zofra ODT 8 does not usually affect your ability to drive.
Kidney
SAFE IF PRESCRIBED
Zofra ODT 8 is safe to use in patients with kidney disease. No dose adjustment of Zofra ODT 8 is recommended. However, inform your doctor if you have an underlying kidney disease. Limited information is available on patients taking this medicine for more than one day.
Liver
CONSULT YOUR DOCTOR
There is limited information available on the use of Zofra ODT 8 in patients with liver disease. Please consult your doctor.
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✔️ Mode of Action:
Ondansetron blocks the action of serotonin in the brain, preventing nausea and vomiting induced by chemotherapy, radiotherapy, or surgery.
✔️ Dosage Recommendations:
Chemotherapy-Induced Nausea and Vomiting
- Adults & Pediatric (6 months to 18 years):
- 8 mg tablet/orodispersible tablet: Three 0.15 mg/kg doses, up to 16 mg per dose.
- 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to 16 mg per dose.
- Injection: Three 0.15 mg/kg doses, up to 16 mg per dose, infused intravenously over 15 minutes.
Radiotherapy-Induced Nausea and Vomiting
- Adults:
- 8 mg tablet/orodispersible tablet: Initial Dose: 8 mg orally 1 to 2 hours before radiotherapy. Post Radiotherapy: 8 mg orally every 8 hours for up to 5 days after a course of treatment.
- 4 mg orodispersible tablet: Three 0.15 mg/kg doses, up to 16 mg per dose.
- Injection: Three 0.15 mg/kg doses, up to 16 mg per dose, infused intravenously over 15 minutes.
Postoperative Nausea and Vomiting
- Adults:
- 8 mg tablet/orodispersible tablet: 16 mg given as two 8 mg tablets.
- 4 mg orodispersible tablet: 16 mg.
- Injection: 4 mg.
- Pediatrics:
- >40 kg: Injection: 4 mg.
- <40 kg: Injection: 0.1 mg/kg.
Oral Solution Dosage:
- Chemotherapy-induced Nausea and Vomiting:
- Adults/Geriatric/Child (12 years or over): Highly emetogenic cancer chemotherapy: 30 ml (24 mg) once 30 minutes before chemotherapy.
- Pediatric (4-11 years): 5 ml (4 mg) 30 minutes before chemotherapy. Subsequent doses every 8 hours for 1-2 days after chemotherapy.
- Radiotherapy induced Nausea and Vomiting: 10 ml (8 mg) 1 to 2 hours before radiotherapy.
- Postoperative Nausea and Vomiting: 20 ml (16 mg) 1 hour before anesthesia.
Oral Soluble Film Administration:
- Tear the pouch carefully.
- Place the film on your tongue to dissolve within 20 seconds.
- Do not chew or swallow the film whole.
- Swallow after the film dissolves with or without liquid.
- Wash your hands after taking the film.
✔️ Quick Suggestions:
- If you vomit within one hour of taking a dose, take another dose.
- Avoid heavy meals; eat small snacks and sip water regularly to prevent dehydration.
✔️ Side Effects:
- Common: Constipation, diarrhea, fatigue, headache.
- Rare: Anaphylaxis, bronchospasm, tachycardia, angina, hypokalemia, shortness of breath.
✔️ Uses:
Prevention of nausea and vomiting associated with chemotherapy, radiotherapy, surgery, gastroenteritis, and pregnancy.
✔️ Use in Special Populations:
- Renal Impairment: No dosage adjustment is needed.
- Hepatic Impairment: Maximal daily dose of 8 mg for severe hepatic impairment.
- Pediatrics: Limited information for children under 4 years of age.
- Elderly: No dosage adjustment is needed.
✔️ Precautions & Warnings:
- Hypersensitivity reactions.
- Not a replacement for gastric or intestinal peristalsis.
- May mask ileus or gastric distension.
✔️ Storage Conditions:
Store at temperatures not exceeding 30ºC in a dry place, protected from light and moisture.
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