Manufacturer/Distributor: Novartis (Bangladesh) Ltd.
Generic Name: Aceclofenac 100 mg Tablet
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Vaxtin 100 is a pain relieving medicine. It alleviates pain and inflammation in conditions like rheumatoid arthritis, ankylosing spondylitis and osteoarthritis. Vaxtin 100 should be taken in the dose and duration as advised by your doctor. It should be taken with food or milk to prevent stomach upset. Taking the medicine regularly at the right times increases its effectiveness. It is important to keep taking the medicine regularly until your doctor tells you it is safe to stop. Vomiting, stomach pain, nausea, and indigestion are some of the common side effects that might be observed on taking this medicine. It may also cause dizziness, drowsiness, or visual disturbances. Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment. Long-term use may lead to serious complications such as stomach bleeding and kidney problems. Vaxtin 100 is not recommended if you are pregnant or breastfeeding.
Uses of Vaxtin 100
Side effects of Vaxtin 100
Common
How to use Vaxtin 100
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Vaxtin 100 is to be taken with food.
How Vaxtin 100 works
Vaxtin 100 is a non-steroidal anti-inflammatory drugs (NSAID). It works by blocking the release of certain chemical messengers that cause pain and inflammation (redness and swelling).
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Brief Description
Indication
Adult: PO Ankylosing spondylitis; Osteoarthritis; Rheumatoid arthritis 100 mg twice daily. SR Tablet : The recommended dose is 200 mg, once daily. Elderly: The pharmacokinetics of aceclofenac are not altered in elderly patients, therefore it is not considered necessary to modify the dose and dose frequency. Hepatic Impairment Reduce initial dose to 100 mg daily .
Administration
May increase plasma concentrations of lithium and digoxin. Increased nephrotoxicity when used with diuretics or ciclosporin. Monitor serum potassium when used with potassium-sparing diuretics and ACE inhibitors. May enhance activity of anticoagulants. May increase risk of methotrexate toxicity when administered within 24 hr of methotrexate admin. Increased risk of GI bleed with other NSAIDs. Increased risk of convulsion with quinolones.
Adult Dose
Cautiously administer to patients with GI disease, ulcerative colitis, Crohn's disease, haematological abnormalities, hepatic porphyria; history of bronchial asthma; history of heart failure or hypertension; mild renal, hepatic or cardiac impairment. May impair ability to drive or operate machinery. Elderly. Patients suffering from severe hepatic impairment must be monitored.
Renal Dose
Aceclofenac, a phenylacetic acid derivative, has antiinflammatory and analgesic properties. It is a potent inhibitor of cyclo-oxygenase which is involved in the production of prostaglandins.
Contraindication
Safety & Efficacy not established.
Mode of Action
Should be taken with food. Take w/ or immediately after meals.
Precaution
Indicated for the relief of pain and inflammation in both acute and chronic pain like, osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, dental pain, post-traumatic pain, low back pain, gynaecological pain.
Side Effect
No dose adjustment needed.
Pregnancy Category Note
Gastrointestinal disorders (dyspepsia, abdominal pain, nausea and diarrhoea) and occasional occurance of dizziness. Dermatological side effects including pruritus and rash. Abnormal hepatic enzyme levels and raised serum creatinine have occasionally been reported. Potentially Fatal: Severe GI bleeding; nephrotoxicity; blood dyscrasias.
Interaction
Hypersensitivity to aspirin or NSAIDs; moderate to severe renal impairment; pregnancy (3rd trimester); history of peptic ulceration or GI bleed; patients with infections.
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