Manufacturer/Distributor: Drug International Ltd.
Generic Name: Ketorolac Tromethamine 10mg
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Indications
Ketorolac Tromethamine is used to treat moderate to severe acute postoperative pain in the short term.
Pharmacology
The non-steroidal anti-inflammatory medication ketorolac tromethamine is a powerful painkiller (NSAID). It works by preventing prostaglandin formation by inhibiting the cyclooxygenase enzyme system. At its analgesic dose, it has a minor anti-inflammatory action.
Dosage & Administration
Tablet-
The recommended dose is 10 mg every 4-6 hours. It should be used short-term only (up to 7 days) and is not recommended for chronic use. Doses exceeding 40 mg/day are not recommended.
Injection-
Ketorolac injection may be used in single or multiple doses, on a regular or when the necessary schedule is for the management of moderately severe, acute pain that requires analgesia at the opioid level, usually in a postoperative setting. When administering Ketorolac injection, the IV bolus must be given over no less than 15 seconds. The IM administration should be given slowly and deeply into the muscle. The analgesic effect begins within 30 minutes with a maximum effect in 1 to 2 hours after dosing IV or IM. The duration of the analgesic effect is usually 4 to 6 hours.
Single-Dose Treatment-
IM Dosing (Adult):
IV Dosing (Adult):
IV or IM Dosing (2 to 16 years of age):
Multiple-Dose Treatment (IV or IM)-
Patients <65 years of age:
Conversion from Parenteral to Oral Therapy:
Interaction
Contraindications
Patients who are hypersensitive to ketorolac or other NSAIDs should avoid taking it. It should not be given to youngsters under the age of sixteen. It's also not a good idea to use it as a pre-surgery analgesic.
Side Effects
Nausea, vomiting, gastro-intestinal hemorrhage, melena, peptic ulcer, pancreatitis, anxiety, sleepiness, headache, excessive thirst, fatigue, bradycardia, hypertension, palpitation, chest discomfort, female infertility, and pulmonary edema are some of the most common adverse effects.
Pregnancy & Lactation
Ketorolac Tromethamine is classified as Category C by the US Food and Drug Administration for use during pregnancy. So, unless the potential benefits to the other outweigh the potential hazards to the unborn, Ketorolac Tromethamine should be avoided during pregnancy and lactating.
Precautions & Warnings
Patients over the age of 65 should be treated with caution. Patients with a current or suspected peptic ulcer, gastrointestinal hemorrhage, asthma, or liver failure should use caution.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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