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D-Rise 200000IU/ml Injection
Cholecalciferol [Vitamin D3] 200000IU/ml Injection
Prevention:
- Infants (on fortified milk): 100,000 IU every 6 months.
- Nursed infants & children <5 yrs: 200,000 IU every 6 months.
- Adolescents: 200,000 IU every 6 months (especially in winter).
- Pregnancy: 100,000 IU in the 6th–7th month.
- Elderly: 100,000 IU every 3 months.
Treatment: 200,000 IU; repeat every 1–6 months as needed.
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✅ Description:
D-Rise (Cholecalciferol) helps prevent and treat Vitamin D3 deficiency, especially in individuals with limited sunlight exposure or insufficient dietary intake. It promotes optimal absorption of calcium and phosphate, which is crucial for healthy bones, teeth, and immune function. Additionally, it plays a key role in preventing rickets, osteomalacia, osteoporosis, and pre-eclampsia during pregnancy.
Vitamin D3 (Cholecalciferol) is absorbed in the small intestine, binds to α-globulins, and is transported to the liver, where it's converted to Calcidiol (25-hydroxyvitamin D3). A second conversion occurs in the kidney to form the active hormone Calcitriol (1,25-dihydroxyvitamin D3). This active form binds to Vitamin D receptors (VDRs) in various tissues, enhancing calcium absorption and supporting bone mineralization. Vitamin D3 is fat-soluble, with a half-life of ~50 days, and is excreted via feces and urine.
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✔️ Side Effects
- Anorexia, nausea, vomiting
- Diarrhea or constipation
- Polyuria, weight loss, headache
- Increased calcium/phosphate levels in blood/urine
✔️ Interactions
Vitamin D3 absorption or metabolism may be reduced by:
- Antiepileptics (phenytoin, phenobarbital)
- Cholestyramine, colestipol, mineral oil, orlistat
- Corticosteroids (e.g., prednisolone)
- Magnesium-containing antacids
- Digoxin, thiazide diuretics
✔️ Contraindications
Hypercalcemia-related conditions
Known hypersensitivity to vitamin D3 or formulation excipients
Signs of vitamin D toxicity
✔️ Pregnancy & Lactation
Safe up to 4,000 IU/day in pregnancy.
Recommended intake: 400 IU/day (may be adjusted by physician based on need).
No evidence of overdose effects in infants via breastfeeding.
✔️ Precautions & Warnings
Monitor serum calcium in high-dose users, renal impairment, pregnancy, or lactation.
Use cautiously in:
- Patients on digoxin or thiazide diuretics
- Those with liver/kidney disease, lymphoma, TB, or granulomatous disorders
- In breastfeeding mothers, vitamin D3 is excreted in milk. Consider total infant exposure when supplementing both mother and child.
✔️ Storage
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
