Neofloxin 250mg 10pcs

Indications of Neofloxin 250 Tablet

Neofloxin 250 is an antibiotic  It cures the infection by preventing the growth of pathogenic microorganisms. 

Ciprofloxacin is used to treat 

• Respiratory Tract Infections
• Urinary Tract Infections
• Pelvic Inflammatory Diseases
• urinary tract infections
• nose, throat, skin, and soft tissues infection
• lungs (pneumonia)
• Typhoid Fever
• Intra-abdominal Infections
• Prostatitis
• Skin and Soft Tissue Infections
• Bone and Joint Infections
• Gonorrhea

Pharmacology of Neofloxin 250 Tablet

Ciprofloxacin is a synthetic fluoroquinolone antibiotic. It is effective against both gram-positive and gram-negative bacteria. It inhibits bacterial DNA synthesis by binding to the bacterial enzymes DNA gyrase and topoisomerase IV, which are responsible for DNA supercoiling.

Dosage of Neofloxin 250 Tablet

Tablet: Adult:

Respiratory Tract Infections: 500 to 750 mg twice daily (7 to 14 days)

Urinary tract infections: 250 to 750 mg twice daily (3 to 10 days)

Pelvic Inflammatory Diseases: 500 to 750 mg twice daily (14 days)

Infectious Diarrhea (Shigella dysenteriae, Vibrio cholera): 500 mg twice daily (1 to 5 days)

Typhoid fever: 500 mg twice daily (7 days)

Intra-abdominal infections: 500 to 750 mg twice daily (5 to 14 days)

Prostatitis: 500 to 750 mg twice daily (2 to 6 weeks)

Skin and Soft Tissue Infections: 500 to 750 mg twice daily (7 to 14 days)

Bone and Joint Infections: 500 to 750 mg twice daily (max. 3 months)

Gonorrhea: 500 mg as a single dose

Neutropenic patients with fever due to bacterial infection: 500 to 750 mg twice daily co-administered with appropriate antibacterial.

Meningitis: 500 mg as a single dose.

Surgical prophylaxis: 500 mg as a single dose, 60 minutes before the procedure.

Suspension: Pediatric: 10-20 mg/kg (max. 750 mg) twice daily (10 to 21 days). The duration of therapy depends on the type and severity of the infection.

Extended-release tablet: The recommended dose of extended-release tablet for uncomplicated urinary tract infection (acute cystitis) is 1000 mg tablet once daily for three days.

For IV infusion:

Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 12 hourly for 7-14 days

Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days

Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days

Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days

Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Complicated: 400 mg 8 hourly for more than 4-6weeks

Intraabdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days

Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for 10 days

Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days.

Administration of Neofloxin 500 Tablet

It is safe to take with or without food. To reduce GI discomfort, take it with meals. Take with caution if you are taking antacids, Fe, or dairy products. Administration of IV fluids Over 60 minutes, infuse 1-2 mg/mL (diluted in D5W or NS) into a large vein.

Interaction of Neofloxin 500 Tablet

Ciprofloxacin should not be combined with magnesium or aluminum antacids, sucralfate, or any calcium, iron, or zinc-containing medications. Ciprofloxacin can be administered two hours after or six hours before these medications. Ciprofloxacin should not be taken with milk or other dairy products because its absorption may be greatly reduced. However, when consumed as part of a meal, dietary calcium has no effect on Ciprofloxacin absorption.

Contraindications

Patients who have a known hypersensitivity to Ciprofloxacin or other quinolones should avoid it.

Side Effects of Neofloxin 500 Tablet

Side effects include- nausea and other gastrointestinal disturbances, headache, dizziness, joint pain, and skin rashes.

Pregnancy & Lactation

In pregnant women, there are no sufficient and well-controlled trials. Only if the possible benefit outweighs the danger to the fetus and mother should Ciprofloxacin be used during pregnancy. Human milk contains ciprofloxacin, which is excreted. Ciprofloxacin should not be taken during lactation due to the risk of articular injury.

Precautions & Warnings

Ciprofloxacin patients should be encouraged to drink plenty of water. It should be used with caution in people who have suspected or established CNS problems, such as epilepsy, or other factors that predispose them to seizures and convulsions. In patients with known QT prolongation, hypokalemia should be avoided.

Storage Conditions

Store in a dry area at a temperature of not more than 30°C. Light and dampness should be avoided. Keep out of children's reach.