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G-Cephalexin Powder for Suspension 100ml
Cephalexin is a semisynthetic first-generation cephalosporin antibiotic. It works by inhibiting the transpeptidase enzyme, disrupting bacterial cell wall synthesis. This weakens the cell wall, causing bacterial swelling and rupture. Cephalexin is effective orally and targets bacterial cell walls by interfering with peptidoglycan cross-linking.
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✅ Description:
G-Cephalexin is indicated for the treatment of infections caused by susceptible organisms, including:
- Respiratory Tract Infections: Acute and chronic bronchitis, infected bronchiectasis.
- Genito-Urinary Tract Infections: Acute and chronic nephritis, cystitis, urethritis, prostatitis, and prophylaxis of recurrent urinary tract infections.
- Skin and Soft Tissue Infections: Infections caused by Staphylococci and/or Streptococci.
- Ear, Nose, and Throat Infections: Otitis media, mastoiditis, sinusitis, follicular tonsillitis, and pharyngitis.
- Bone Infections: Caused by Staphylococci and/or Proteus mirabilis.
✔️ Dosage & Administration
Adults:
- Usual dose: 250 mg to 500 mg every 6 hours.
- For skin and soft tissue infections, streptococcal pharyngitis, or uncomplicated cystitis (in patients >15 years): 500 mg every 12 hours.
- Severe or deep-seated infections: The dose can be increased from 3 g to 6 g daily.
Children:
- Dosage: 25-100 mg/kg/day divided into multiple doses, with a maximum of 4 g daily.
Children’s Weight-Based Dosing:
- 10 kg: 62.5-125 mg 4 times daily or 125-250 mg twice daily.
- 20 kg: 125-250 mg 4 times daily or 250-500 mg twice daily.
- 40 kg: 250-500 mg 4 times daily or 500 mg-1 g twice daily.
Specific Conditions:
- Streptococcal Pharyngitis, Skin, and Soft Tissue Infections: Administer every 12 hours for patients >1 year old.
- Otitis Media: Requires 75-100 mg/kg/day divided into 4 doses.
- Beta-Hemolytic Streptococcal Infections: Treatment should last at least 10 days.
✔️ Pregnancy & Lactation
- Pregnancy: Category B. Cephalexin can be used if deemed essential.
- Lactation: Cephalexin is excreted in breast milk; use with caution in nursing mothers.
✔️ Side Effects
Common side effects:
- Nausea, vomiting, diarrhea, abdominal discomfort.
- Rarely: Pseudomembranous colitis, skin rash, angioedema, elevated serum aminotransferases, eosinophilia, neutropenia, and superinfection (e.g., Candida).
✔️ Contraindications
- Hypersensitivity to cephalosporin antibiotics.
✔️ Precautions & Warnings
- Use cautiously in patients with renal impairment; dosage adjustments may be necessary.
- Cephalexin may give false-positive results in urine glucose tests using copper reduction reagents and in Coombs' tests.
- Although no teratogenic effects were noted in animal studies, use only if essential during pregnancy.
✔️ Storage Conditions
- Store in a cool, dry place away from moisture and heat. Keep out of reach of children.
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