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Lescol XL 80mg (Box)
Lescol XL is an HMG-CoA reductase inhibitor (statin) used as an adjunctive therapy to diet for:
- Primary hypercholesterolemia and mixed dyslipidemia (Adults):
- Reduces total cholesterol (TC), LDL-C, Apo B, and triglycerides (TG).
- Increases HDL-C levels.
- Heterozygous familial hypercholesterolemia (Children aged 10–16):
- Reduces elevated TC, LDL-C, and Apo B after failing dietary therapy.
- Clinically evident CHD:
- Reduces the risk of revascularization procedures.
- Atherosclerosis in CHD patients:
- Slows its progression.
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✅ Description:
Lescol XL 80 Tablet (Fluvastatin) is a statin medication primarily used to:
- Lower bad cholesterol (LDL) and triglycerides (TG) levels in the blood.
- Increase good cholesterol (HDL) levels.
- Reduce the risk of heart attacks and strokes by preventing cholesterol buildup in the arteries.
High cholesterol levels (hyperlipidemia or dyslipidemia) can cause arterial narrowing or blockages, leading to coronary heart disease, strokes, or heart attacks. Lescol XL 80 Tablet helps manage cholesterol levels, thereby lowering these risks.
How Lescol XL 80 Tablet Works:
The active ingredient, Fluvastatin, inhibits HMG-CoA reductase, an enzyme in the liver responsible for cholesterol synthesis.
- Reduces LDL (bad cholesterol) production.
- Decreases cholesterol buildup in major blood vessels of the brain and heart.
- Minimizes the risk of atherosclerosis, stroke, and heart attacks.
- Take Lescol XL 80 Tablet exactly as prescribed by your doctor.
- Do not crush, break, or chew the tablet.
- Can be taken with or without food, ideally at the same time each day.
- Do not double up on missed doses; simply take the next dose as scheduled.
- Inform your doctor if you are allergic to Lescol XL 80 Tablet or any other statins.
- Contraindicated during pregnancy and breastfeeding.
- Use effective birth control measures while on this medication.
- Avoid alcohol as it can increase the risk of liver damage.
- Do not take if you have active liver disease or persistently high liver enzymes (transaminases).
- Inform your doctor if you are about to undergo any surgery.
- If you experience unexplained muscle weakness or dark-colored urine, which may indicate serious side effects like myopathy or rhabdomyolysis.
✔️ Uses:
Treatment of Hyperlipidemia (high cholesterol)
✔️ Common adverse reactions (≥2% incidence):
- Headache
- Dyspepsia
- Myalgia
- Abdominal pain
- Nausea
✔️ Pharmacology
Fluvastatin works by inhibiting HMG-CoA reductase, an enzyme necessary for cholesterol synthesis in the liver. This:
- Reduces total cholesterol, LDL, and VLDL.
- Increases HDL levels.
- Lowers plasma triglycerides.
✔️ Dosage: General Guidelines:
- Dose range: 20–80 mg/day, taken as a single dose, with or without food.
- Do not break, crush, chew, or open capsules.
- A maximal effect is seen within 4 weeks; lipid levels should be periodically monitored.
Adults:
- Starting dose: 40 mg capsule in the evening OR 40 mg twice daily.
- Alternatively, 80 mg once daily (Lescol XL).
Pediatric Patients (10–16 years):
- Starting dose: 20 mg once daily.
- Adjust up to 40 mg twice daily or 80 mg once daily at 6-week intervals, based on therapy goals.
✔️ Drug Interactions
- Cyclosporine/Fluconazole:
- Increased Lescol XL exposure; limit dose to 20 mg/day.
- Lipid-lowering therapies (e.g., fibrates, niacin):
- Increased risk of myopathy/rhabdomyolysis.
- Glyburide:
- Monitor blood glucose if the Lescol XL dose is changed.
- Phenytoin:
- Monitor plasma levels when Lescol XL is started or dose adjusted.
- Warfarin and derivatives:
- Monitor prothrombin time during co-administration or dose changes.
✔️ Contraindications
- Hypersensitivity to any component of Lescol XL.
- Active liver disease or unexplained, persistent elevations in serum transaminases.
- Pregnant or nursing women.
✔️ Pregnancy & Lactation
- Pregnancy: Contraindicated as it may harm fetal development. Cholesterol is essential during pregnancy, so lipid-lowering drugs should be discontinued.
- Nursing: Fluvastatin is secreted into breast milk and may harm infants. Nursing mothers requiring treatment should avoid breastfeeding.
✔️ Precautions & Warnings
- Skeletal Muscle Effects (Myopathy/Rhabdomyolysis):
- Risk factors: Age >65, hypothyroidism, renal impairment, combination with cyclosporine or gemfibrozil.
- Discontinue if myopathy is diagnosed/suspected.
- Liver Enzyme Abnormalities:
- Persistent transaminase elevation can occur.
- Monitor liver function tests before starting therapy and as needed.
✔️ Storage
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
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