Generic Name: Esomeprazole 40mg
Company Name: Radiant Pharmaceuticals Ltd.
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Indication
Exium Mups 40 is a medication that lessens the quantity of acid your stomach produces. Heartburn, acid reflux, and issues with your food pipe are all treated with it. Stomach ulcers can also be prevented and treated with them. Exium Mups 40 should be taken as prescribed by your doctor.
Pharmacology
Esomeprazole may be a proton pump inhibitor that prevents the production of gastric acid by specifically impairing the H+/K+ ATPase found in the gastric parietal cell. The principal single optical isomer of proton pump inhibitors, esomeprazole (S-isomer of omeprazole), provides better corrosive control than racemic proton pump inhibitors.
Dosage and administration
Exium MUPS tablets are to be ingested whole along with some fluids. Both chewing and crushing the tablets are not advised. The pills can also be dissolved, if necessary, in half a glass of non-carbonated water (mineral water is not suitable). Use of any other liquids is prohibited. Drink the liquid containing the pellets right away or within 30 minutes after stirring until the tablets have broken down. Drink after rinsing the glass with a half-glass of water. It is forbidden to eat or crush the pellets.
children aged 1 to 11:
Erosion of the esophagus
10 mg once daily for the maintenance of erosive esophagitis healing
Interaction of Exium Mups 20
CYP2C19 and CYP3A4 substantially metabolize Exium Mups 20 in the liver. Esomeprazole is not expected to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4, according to in vitro and in vivo research. There shouldn't be any clinically significant interactions with medications that these CYP enzymes process. According to studies on drug interactions, esomeprazole does not interact clinically with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin. The main enzyme that metabolizes esomeprazole, CYP2C19, may be affected by esomeprazole. Diazepam's clearance was reduced by 45% when Esomeprazole 30 mg and diazepam, a CYP2C19 substrate, were taken together. Diazepam plasma levels have been seen to rise 12 hours after dosage and beyond. Esomeprazole reduces the production of stomach acid. As a result, esomeprazole may prevent the absorption of medications whose bioavailability is significantly influenced by gastrointestinal pH. (e.g., ketoconazole, iron salts, and digoxin)
Contraindication
Patients who have a history of recognized hypersensitivity to any formulation ingredient or to substituted Benzimidazoles should not take esomeprazole.
Side Effects of Exium Mups 20
There is no difference in types of related adverse events seen during maintenance treatment up to 12 months compared to short-term treatment. The most frequently occurring adverse events reported with Esomeprazole include:
Pregnancy and lactation
Pregnancy The S-isomer of omeprazole, esomeprazole, has not been adequately studied in pregnant women, and the available epidemiologic data do not support a link between first-trimester omeprazole use and an increased risk of significant congenital abnormalities or other negative pregnancy outcomes. The dosage-dependent embryo-lethality observed in reproduction tests in rats and rabbits occurred at omeprazole doses that ranged from 3.4 to 34 times the 40 mg oral human dose (based on a body surface area for a 60 kg person) There are no clinical studies on the effects of esomeprazole on breastfed infants or milk supply. Esomeprazole is the S-isomer of omeprazole, and limited evidence indicates that omeprazole may be found in human milk.
Along with the mother's clinical requirement for therapy and any potential negative effects on the breastfed child from treatment or from an underlying maternal ailment, the developmental and health benefits of nursing should be taken into consideration.
Precautions & Warnings
Exium Mups 40 should be used carefully if the patient has severe liver dysfunction and severe renal impairment. Taking a proton pump inhibitor like Esomeprazole may slightly increase the risk of hip, wrist, and spine fracture, particularly when it is taken over a period of more than one year.
Storage Conditions
Store in a cool & dry place below 25º C, protect from light.
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