Gefinix 250mg 10pcs
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Gefinix 250mg 10pcs

Type: Tablet

Pack Size: 10 Pcs

Generic Name: Gefitinib 250mg 

Company Name: Beacon Pharmaceuticals Limited


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Discount Price: ৳ 2325
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Description:

Indications

Gefinix 250 is a medication used to treat non-small cell lung cancer. It is used in patients whose cancer has spread to other parts of their bodies, who have abnormal epidermal growth factor receptor (EGFR) genes, and who have not previously received cancer treatment. Gefinix 250 can be taken with or without food, but for best results, take it at the same time every day. You should continue to take it for as long as your doctor recommends.

Pharmacology

Gefitinib binds to and inhibits the adenosine triphosphate (ATP)-binding site of the epidermal growth factor receptor (EGFR) tyrosine kinase. The function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is thus prevented, and malignant cells are suppressed as a result. Gefitinib is the first and only EGFR tyrosine kinase inhibitor that is also known as Her1 or ErbB-1. EGFR is overexpressed in the cells of certain types of human carcinomas, such as lung and breast cancer. Overexpression inappropriately activates the apoptotic Ras signal transduction cascade, resulting in uncontrolled cell growth.

Dosage & Administration

The recommended dose of Gefitinib is 250 mg orally once daily with or without food until disease progression or unacceptable toxicity. Do not take a missed dose within 12 hours of the next dose.

Interaction

Use of CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, barbiturates) along with gefitinib may lower serum levels. Potent CYP3A4 inhibitors may raise plasma concentrations (e.g. itraconazole, ketoconazole). Warfarin can cause an increase in INR or bleeding. Metoprolol levels in the blood may rise. Vinorelbine-induced neutropenia may be exacerbated. Drugs that change stomach pH can cause decreased plasma levels and possibly reduced efficacy (e.g. PPIs, H2-receptor antagonists).

Contraindications

Hypersensitivity. Lactation.

Side Effects

The following adverse reactions have been reported with Gefitinib across NSCLC trials: nausea (18%), asthenia (17%), pyrexia (9%), alopecia (4.7%), hemorrhage (including epistaxis and hematuria) (4.3%), dry mouth (2%), dehydration (1.8%), allergic reactions including angioedema and urticaria (1.1%), elevations in blood creatinine (1.5%), and pancreatitis (0.1%).

Pregnancy & Lactation

D is the pregnancy category. Although there is evidence of human fetal danger, the advantages of usage in pregnant women may outweigh the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Precautions & Warnings

Patients with idiopathic pulmonary fibrosis, new or worsening pulmonary or eye symptoms. Renal and hepatic dysfunction Pregnancy. Parameters for monitoring Regularly check your liver function, prothrombin time, and INR. Lactation Unknown; not recommended if distributed in 

Storage Conditions

Store between 20-25° C.

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Check our pricing section for Gefinix 250mg 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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