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Bromazepam is a short-acting benzodiazepine with intermediate onset commonly used to treat panic disorders and severe anxiety.
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✅ Description:
Freten is indicated for:
- Emotional disturbances such as acute tension and anxiety states, interpersonal difficulties, agitation, insomnia, and anxious/agitated depressive reactions.
- Functional disturbances in the cardiovascular and respiratory systems, including pseudo angina pectoris, pericardial anxiety, tachycardia, monogenic hypertension, dyspnea, and hyperventilation.
- Gastrointestinal disturbances like irritable bowel syndrome, epigastric pain, spasms, bloating, and diarrhea.
- Urinary tract disturbances, including frequency, irritable bladder, and dysmenorrhea.
- Psychosomatic disorders such as psychogenic headache, asthma, and gastric/duodenal ulcers.
- Emotional reactions to chronic organic diseases.
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✔️ Uses of Freten 3mg Tablet
Freeten 3mg is indicated for the treatment of:
- Anxiety
- Panic attacks
✔️ How does Freten 3mg Tablet work?
Bromazepam binds to the GABA-A receptor producing a conformational change and potentiating its inhibitory effects. Other neurotransmitters are not influenced.
✔️ Side Effects:
- Common: Fatigue, drowsiness, muscle weakness, numbed muscle, reduced alertness, confusion, headache, ataxia. These symptoms are more common at the start of therapy and usually subside with continued use.
- Anterograde amnesia may occur at therapeutic doses.
✔️ Indications:
Bromazepam is a benzodiazepine with properties similar to diazepam, used to treat anxiety alone or associated with insomnia.
✔️ Pharmacology
- Bromazepam is a potent psychotropic agent. At lower doses, it reduces tension and anxiety selectively, while at higher doses, it exhibits sedative and muscle-relaxant properties.
- Bromazepam binds to the GABA-A receptor, inducing a conformational change that potentiates its inhibitory effects without influencing other neurotransmitters.
✔️ Dosage & Administration
- Standard Dosage: The average outpatient dose is 1.5-3 mg up to three times daily. Start with low doses and gradually increase to the optimal level.
- Severe Cases (especially in hospital): 6-12 mg 2 or 3 times daily. Treatment should generally not exceed 8-12 weeks. Extensions beyond this period require a re-evaluation of the patient's status.
- Elderly and Debilitated Patients: Require lower doses due to impaired hepatic function.
- Children: Typically not indicated. If deemed necessary, adjust the dose according to low body weight (approximately 0.1-0.3 mg/kg body weight).
Administration
- Oral Administration: Tablets should be taken orally.
- Note: Always follow the physician's advice for dosage and administration.
✔️ Interaction
- CYP450 inhibitors (e.g., azole antifungals, macrolides, HIV protease inhibitors, Ca channel blockers): May enhance activity
- Disulfiram or cimetidine: Elevated plasma levels
- Barbiturates, sedatives, anesthetics, anxiolytics, hypnotics, phenothiazines, other antipsychotics, skeletal muscle relaxants: Additive CNS depressant effects
- Atropine, antihistamines, and antidepressants: May potentiate anticholinergic effects
- Narcotic analgesics: Increased psychic drug dependence
✔️ Contraindications
- Known hypersensitivity to bromazepam
- Severe respiratory insufficiency
- Severe hepatic insufficiency
- Sleep apnea syndrome
✔️ Pregnancy & Lactation
- The safety of bromazepam during pregnancy is not established.
- As bromazepam is excreted in breast milk, it should be avoided during lactation.
✔️ Precautions & Warnings
- Chronic pulmonary insufficiency
- Elderly or debilitated patients
- Muscle weakness
- Impaired liver or kidney function
- Drowsiness may affect skilled tasks
- Monitor cardio-respiratory function when used for deep sedation
- Patients with personality disorders or organic brain changes
- Pregnancy and lactation
- History of alcohol or drug addiction due to the risk of dependence
- Respiratory depression and hypotension with parenteral administration; this route should only be used when facilities for reversing respiratory depression are available.
✔️ Storage Conditions:
- Store in a dry place away from light and heat.
- Keep out of reach of children.
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