Nidocard 400mcg Spray

✔️ Side Effects: Nidocard 400mcg Spray

• Headache
• Dizziness
• Lightheadedness
• Low blood pressure
• Increased heart rate
• Blurred vision
• Flushing
• Tingling or prickling sensation
• Nausea or vomiting
• Dry mouth

✔️ Mode of Action

Glyceryl trinitrate releases nitric oxide, which activates guanylate cyclase in vascular smooth muscle. This causes relaxation and dilation of blood vessels.

The resulting reduction in venous return lowers cardiac preload and oxygen demand. Arterial dilation can also reduce afterload, while coronary vasodilation and relief of coronary spasm may improve blood flow to the heart. These effects help relieve and prevent anginal chest pain.

✔️ How to Use Nidocard Spray

• Use Nidocard Spray exactly as directed by your doctor or according to the product instructions.
• For an acute angina attack, the spray is generally administered onto or under the tongue. Do not inhale the spray. After administration, avoid rinsing the mouth or swallowing unnecessarily for several minutes.
• A commonly used regimen for acute angina is 1–2 sprays when symptoms begin, which may be repeated every 3–5 minutes if required, without exceeding 3 sprays within 15 minutes.
• If chest pain continues after the recommended maximum number of doses, seek emergency medical attention immediately.
• For prevention, 1–2 sprays may be used approximately 5–10 minutes before an activity that is expected to trigger angina, if prescribed by your doctor.
• Do not exceed the prescribed dose.

✔️ Nidocard Spray should not be used in patients with:

• Known allergy or hypersensitivity to glyceryl trinitrate or other nitrates
• Severe hypotension
• Severe anemia
• Hypertrophic obstructive cardiomyopathy
• Cerebral hemorrhage or recent head trauma
• Raised intracranial pressure
• Severe hypovolemia causing reduced cardiac output
• Certain cases of inferior myocardial infarction involving the right ventricle
• Concomitant use of PDE-5 inhibitors such as sildenafil or tadalafil

✔️ Nidocard Spray may interact with several medicines:

• Sildenafil, tadalafil, vardenafil, and other PDE-5 inhibitors: May cause a severe and potentially life-threatening drop in blood pressure.
• Alcohol: May significantly increase hypotension, dizziness, and risk of collapse.
• Calcium-channel blockers and antihypertensive medicines: May enhance the blood-pressure-lowering effect.
• Phenothiazines and tricyclic antidepressants: May increase the risk of orthostatic hypotension.
• Aspirin and other NSAIDs: May alter the therapeutic response to glyceryl trinitrate.
• Some medicines that cause severe dry mouth may reduce the effectiveness of sublingual preparations by interfering with dissolution and absorption.
• Glyceryl trinitrate may interact with certain medicines used in cardiovascular and surgical settings.

✔️ Use Nidocard Spray carefully in patients with:

• Severe liver or kidney impairment
• Hypothyroidism
• Malnutrition
• Hypothermia
• Cerebrovascular disease
• Lung disease or cor pulmonale
• Glaucoma
• Mitral valve prolapse
• Cardiac tamponade
• A history of fainting or low blood pressure

✔️ How Nidocard Spray Works

Nidocard Spray is a nitrate medicine. Glyceryl trinitrate produces nitric oxide in the body, which relaxes vascular smooth muscle and widens blood vessels.

This reduces the amount of blood returning to the heart and lowers the heart's workload and oxygen requirement. It can also improve coronary blood flow and relieve coronary artery spasm, helping to reduce or prevent angina.

✔️ Adult Dose | Nidocard 400mcg Spray

Acute angina:
Use 1–2 sprays as required at the onset of angina. The dose may be repeated every 3–5 minutes, but no more than 3 sprays should be used within 15 minutes.

If symptoms persist after 3 doses, urgent medical attention should be obtained.

Prevention of angina:
1–2 sprays may be administered approximately 5–10 minutes before an activity likely to provoke an angina attack, as advised by a healthcare professional.

Other forms of glyceryl trinitrate, such as sustained-release tablets or intravenous preparations, have different dosing schedules and should not be substituted for the spray without medical advice.

✔️ Renal Impairment

Patients with significant kidney impairment may require individualized dosing and monitoring. Treatment should be guided by the patient's renal function and overall clinical condition.

✔️ Storage:

Store Nidocard Spray according to the manufacturer's instructions. Keep it protected from excessive heat, moisture, and direct light, and keep it out of the reach of children.