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Glifo-M is a combination of Empagliflozin and Metformin, indicated for adults with type 2 diabetes mellitus as an adjunct to diet and exercise. It is used in patients whose blood sugar remains inadequately controlled with Metformin alone, in combination with other antidiabetic medicines, or in those already receiving Empagliflozin and Metformin as separate tablets.
Treatment should be individualized based on efficacy and tolerability. Glifo-M is generally taken twice daily with meals to minimize gastrointestinal side effects associated with Metformin. Dose adjustments should be made gradually.
The maximum recommended daily dose is Empagliflozin 25 mg and Metformin 2000 mg.
Glifo-M is generally not recommended during pregnancy, particularly during the second and third trimesters. It is also not recommended while breastfeeding.
Empagliflozin overdose has not shown significant toxicity in clinical studies. Excessive Metformin intake may lead to lactic acidosis, a medical emergency requiring immediate hospital treatment. Hemodialysis can effectively remove Metformin and lactate from the body.
Regular monitoring of kidney function, blood glucose levels, and vitamin B12 status may be necessary during treatment.
Less common but serious effects may include:
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.
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