Ketifen 1mg Tablet

Uses of Ketifen 1mg Tablet

To prevent:

• Bronchial asthma
• Rhinitis

How does Ketifen 1mg Tablet work?

Ketifen 1mg Tablet works by blocking histamine (a substance in the body that causes allergic symptoms) and stops the release of mediators from cells involved in hypersensitivity reactions.

Side Effects of Ketifen 1mg Tablet

• Irritation or Irritability
• Drowsiness
• Hyperactivity reactions
• Agitation
• Irritability
• Inability to sleep (insomnia)
• Burning sensation when passing urine and need to urinate frequently (cystitis)
• Dry mouth
• Weight increased
• Sleep disturbances or Inability to sleep (insomnia)
• Agitation or Nervousness

Quick Suggestions:

• Stay hydrated: It is important to drink plenty of fluids, such as water, herbal tea, or warm broth, to help soothe a cough, relieve a runny nose, and prevent dehydration.
• Manage stress: Stress can weaken the immune system, making you more susceptible to illnesses. Engage in activities that help reduce stress, such as regular exercise, meditation, deep breathing exercises, or practicing progressive muscle relaxation techniques.
• Prioritize sleep: Aim for 7-9 hours of quality sleep each night. Adequate rest helps support a strong immune system and aids in the body's recovery from illness.
• Avoid allergens: If you are aware of specific allergens that trigger your symptoms, such as pollen or dust, take steps to minimize exposure. Keep windows closed during high pollen seasons, use air purifiers, and dust and vacuum regularly.
• Identify and manage food allergies: Pay attention to any specific food items that may cause allergic reactions in your case. If you suspect food allergies, it is advisable to consult with a healthcare professional for proper evaluation and guidance.
• Practice good personal hygiene: Regularly washing hands with soap and water, especially before meals and after being in public places, helps reduce the spread of germs. Additionally, keeping your surroundings clean and practicing good hygiene habits can minimize the risk of infections.

Indication

Bronchial asthma is a disorder in which the airways constrict and swell, causing excessive mucus production. This can make breathing difficult, as well as cause coughing, wheezing, and shortness of breath. It is used in the prophylactic treatment of bronchial asthma and allergic conditions such as rhinitis (inflammation of the inside of the nose caused by an allergen like pollen, or dust).

Pharmacology

Ketotifen is known for its anti-allergic properties and is commonly used in the preventive treatment of asthma, similar to sodium cromoglycate. It exhibits antihistamine characteristics as well. Ketotifen is particularly effective in preventing asthma attacks and has strong anti-anaphylactic effects.

One of the unique features of Ketotifen is its long-lasting inhibitory effect on histamine reactions, which sets it apart from its anti-anaphylactic effects. Research has shown that orally administered Ketotifen is as effective as selective mast cell stabilizers delivered through inhalation in individuals with asthma, with antihistamines proving to be less successful in similar tests.

Long-term clinical trials have been conducted to evaluate the effectiveness of Ketotifen. These studies have demonstrated a reduction in the number, severity, and duration of asthma attacks, and in some cases, patients experienced complete freedom from attacks. Gradual reduction of corticosteroids and/or bronchodilators was also possible in some cases.

It is important to note that Ketotifen does not provide immediate relief for ongoing asthma episodes. Its prophylactic activity may take several weeks to fully establish. Therefore, it is not intended for use during an acute asthma attack.

It is advisable to consult with a healthcare professional for proper evaluation, prescription, and guidance on the use of Ketotifen for asthma management.

Dosage & Administration of Ketifen 1mg Tablet

The recommended dosage of Ketotifen varies based on the age group:

• Adults: The typical dosage for adults is 1 mg taken twice a day with food. In severe cases or as determined by a healthcare professional, the dose can be increased to 2 mg taken twice daily if necessary.
• Children over the age of three: Children in this age group usually take 1 mg of Ketotifen twice a day with food. For the initial few days or as prescribed by the physician, children who are prone to sedation may start with a lower dose of 0.5 to 1 mg at night.
• Elderly individuals: The same dosage as prescribed for adults is generally suitable for the elderly. However, it is advisable to follow the guidance of a healthcare professional for appropriate dosing in this population.

Administration: 

• Swallow Ketifen 1mg Tablet with a glass of water. 
• Do not crush or chew the medicine. 
• It is crucial to adhere to the recommended dosage instructions provided by the healthcare professional. 
• They may adjust the dosage based on the individual's response to the medication and the severity of the condition.

Interaction

Ketifen 1mg Tablet may interact with certain medications and disease conditions. Here are the potential interactions to be aware of:

Medication Interactions:

• Other antihistamines (e.g., diphenhydramine): Concurrent use of Ketifen 1mg Tablet with other antihistamines can increase the risk of side effects and sedation. It is advisable to avoid combining multiple antihistamines without medical supervision.
• Antidepressants (e.g., doxepin): Combining Ketifen 1mg Tablet with certain antidepressants, such as doxepin, can enhance the sedative effects and increase the risk of drowsiness. Close monitoring and dosage adjustments may be necessary if using these medications together.
• Anticoagulants (e.g., warfarin): Ketifen 1mg Tablet may potentially interact with anticoagulant medications like warfarin, leading to an increased risk of bleeding. Regular monitoring of blood clotting parameters is crucial when using these medications concurrently.
• Hypoglycemic drugs (e.g., metformin): There may be a potential interaction between Ketifen 1mg Tablet and hypoglycemic drugs like metformin. Close monitoring of blood sugar levels is advised when these medications are used together.

Disease Interactions:

• Epilepsy: Ketifen 1mg Tablet may affect seizure thresholds and could potentially worsen epilepsy. Caution is advised when using Ketifen 1mg Tablet in patients with epilepsy, and close monitoring by a healthcare professional is necessary.
• Liver insufficiency: Patients with liver insufficiency may experience slower clearance of Ketifen 1mg Tablet, leading to an increased risk of side effects. Adjustments to the dosage or frequency of administration may be necessary for individuals with liver impairment.

Contraindications

Although there is limited evidence of a teratogenic (causing birth defects) impact of Ketotifen, it is generally not recommended to use Ketotifen during pregnancy or when breastfeeding is not possible. Additionally, there have been reports of a reversible decrease in platelet count in a small number of patients taking Ketotifen along with oral antidiabetic medication. Therefore, it is advisable to avoid the combination of Ketotifen with oral antidiabetic medication.

Pregnancy & Lactation

Ketotifen is not indicated for use during pregnancy or lactation, even though there is a lack of evidence suggesting teratogenic effects. The safety of Ketotifen during these periods has not been sufficiently studied, and it is generally recommended to avoid its use as a precautionary measure. It is important to consult with a healthcare professional for appropriate advice and alternative treatment options if needed, specifically during pregnancy or while breastfeeding.

Precautions & Warnings

• Ketifen 1mg Tablet should not be taken if you are allergic to Ketotifen or any of its ingredients. It is important to inform your doctor about any allergies you may have.
• Ketifen 1mg Tablet may interact with epilepsy and liver impairment. Caution should be exercised when using Ketifen 1mg Tablet in individuals with these conditions. Close monitoring by a healthcare professional is recommended.
• Alcohol consumption should be avoided while taking Ketifen 1mg Tablet to minimize the potential for adverse effects such as dizziness.
• Before taking Ketifen 1mg Tablets, it is important to inform your doctor about your medical history, including any underlying conditions and medications you are currently taking. This will help rule out any potential adverse effects or drug interactions.
• Although there is no evidence of teratogenic consequences associated with Ketifen 1mg Tablet, its use during pregnancy is not recommended. It is advisable to discuss with your healthcare professional the potential risks and benefits of using Ketifen 1mg Tablet during pregnancy.
• Ketifen 1mg Tablet is excreted into human milk. Therefore, mothers receiving the medication should not breastfeed to avoid exposing the infant to the drug.

Storage Conditions

Protect from light and store in a cool, dry location. Keep out of children's reach.