Evo 500mg Tablet

Uses of Evo 500mg Tablet

• Treatment of Bacterial Infections

How does Evo 500mg Tablet work?

Levofloxacin in Evo 500mg Tablet works by preventing bacterial growth by interfering with the action of specific enzymes in bacteria like DNA gyrase and topoisomerase IV that helps in DNA replication, repair, and recombination in bacteria.

Quick Suggestions:

• Your doctor has prescribed Levofloxacin to cure your infection and improve symptoms.
• Do not skip any doses and finish the full course of treatment even if you feel better.
• Discontinue Levofloxacin and inform your doctor immediately if you get a rash, itchy skin, swelling of your face and mouth, or difficulty in breathing.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools.
• Notify your doctor if you feel pain in your tendons, numbness, or tingling sensations.
• Inform your doctor if you are pregnant or planning to conceive or breastfeeding.

Indication of Evo 500mg Tablet

• Acute sinusitis: It is an inflammation of the sinuses, and Evo 500mg Tablet can help in treating bacterial infections associated with it.
• Lung infections: Evo 500mg Tablet is effective in treating lung infections, including long-term breathing problems such as chronic bronchitis and pneumonia.
• Urinary tract infections: This antibiotic is used to treat urinary tract infections, which can affect the kidneys, bladder, and other parts of the urinary system.
• Prostate gland infections: Evo 500mg Tablet can be used to treat bacterial infections of the prostate gland, which can cause discomfort and urinary problems.
• Skin and soft tissue infections: Evo 500mg Tablet is also effective in treating infections of the skin and soft tissues, including muscles. It can help in managing conditions such as cellulitis, which is a skin infection.
• Inhalation Anthrax: Anthrax is a rare but serious bacterial illness caused by Bacillus anthracis. It is transmitted through air, food, and water contaminated with anthrax spores. Evo 500mg Tablet is used for the treatment of inhalation of anthrax that occurs when you breathe in anthrax spores.
• Plague: Plague is a serious bacterial infection caused by Yersinia pestis. It is spread through contact with infected fleas. Evo 500mg Tablet is used in the treatment of plaque.

Additionally, Evo 500mg Tablet can be used as a preventive measure to reduce the risk of developing anthrax (a serious bacterial infection) or worsening of the disease after exposure to anthrax-causing bacteria.

Pharmacology

Levofloxacin exerts its antibacterial action by inhibiting two essential enzymes in bacteria: DNA gyrase and topoisomerase IV. These enzymes are crucial for DNA replication, transcription, repair, and recombination in bacteria.

By inhibiting DNA gyrase, Levofloxacin prevents the supercoiling of bacterial DNA, which is necessary for DNA replication and transcription. This inhibition disrupts the bacterial cell's ability to synthesize new DNA and RNA.

Similarly, by inhibiting topoisomerase IV, Levofloxacin interferes with the separation of DNA strands during cell division, leading to the formation of abnormal DNA structures and ultimately inhibiting bacterial cell division

Dosage & Administration of Evo 500mg Tablet

Adults:

1. Acute sinusitis: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days.
2. Exacerbation of chronic bronchitis: 500 mg once daily for 7 days, 750 mg once daily for 3 days (Uncomplicated), 750 mg once daily for 5 days (Complicated).
3. Community-acquired pneumonia: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days.
4. Uncomplicated urinary-tract infections: 250 mg once daily for 3 days.
5. Complicated urinary tract infections and acute pyelonephritis: 250 mg once daily for 7-10 days.
6. Uncomplicated skin and soft-tissue infections: 500 mg once daily for 7-10 days.
7. Complicated skin and soft-tissue infections: 750 mg once daily for 7-14 days.
8. Enteric fever: 500 mg once daily for 7-14 days.
9. Diarrhea, cholera, shigellosis & enteritis:
   • Mild to moderate case: 500 mg (single dose).
   • Moderate to severe case: 500 mg once daily for 3 days.

Children:

1. Children 6 months to <5 years: 10 mg/kg every 12 hours.
2. Children >5 years: 10 mg/kg every 24 hours.

It's essential to follow the prescribed dosage and duration of treatment as directed by the doctor to ensure effective treatment and minimize the risk of antibiotic resistance. If there are any concerns or questions about the dosage or usage of Levofloxacin, it's always best to consult a healthcare professional for guidance.

Interaction

It is important to note the potential drug-drug interactions, drug-food interactions, and drug-disease interactions associated with Levofloxacin. Here are the interactions to be aware of:

Drug-Drug Interactions:

• Pain-relieving drugs (NSAIDs): Levofloxacin may increase the risk of seizures when taken concomitantly with NSAIDs.
• Acidity relievers (cimetidine): Cimetidine may increase the blood levels of levofloxacin, leading to an increased risk of side effects.
• Anti-tuberculosis drugs (probenecid): Probenecid may increase the blood levels of levofloxacin, leading to an increased risk of side effects.
• Immunosuppressants (cyclosporin): Cyclosporin may increase the blood levels of levofloxacin, leading to an increased risk of side effects.
• Anti-bacterial drugs (macrolides): Concomitant use of levofloxacin with macrolide antibiotics may increase the risk of heart rhythm disturbances.
• Blood sugar-lowering drugs (insulin, glibenclamide): Levofloxacin may increase the blood sugar-lowering effects of these medications, leading to hypoglycemia.
• Blood thinners (warfarin): Levofloxacin may increase the effects of warfarin, leading to an increased risk of bleeding.
• Fits medications (phenytoin, valproate): Levofloxacin may decrease the blood levels of these medications, reducing their effectiveness.

Drug-Food Interaction:

• Levofloxacin should be avoided with milk and yogurt. These dairy products may decrease the absorption of levofloxacin, reducing its effectiveness.

Drug-Disease Interaction:

• Levofloxacin should be used with caution or only after consulting a doctor for conditions such as swollen intestines (colitis), weak muscles (myasthenia gravis), swollen tendons (tendonitis), high blood sugar (diabetes), hemodialysis (kidney dialysis), kidney dysfunction, and nerve diseases.

It is crucial to discuss any existing medical conditions, medications, and dietary habits with your doctor or healthcare professional before taking Levofloxacin to ensure safe and effective treatment. They can provide personalized advice and adjust the treatment plan accordingly.

Contraindications

Levofloxacin should not be used in patients with known hypersensitivity or allergy to levofloxacin, other quinolone antibiotics, or any other component of the medication. It is also not recommended for use in children below 18 years of age. 

Pregnancy & Lactation

Levofloxacin is not recommended for use during pregnancy or while breastfeeding due to the uncertainty of its effects on the unborn child or nursing infant. The safety of levofloxacin during pregnancy has not been well-established, and it may pose a risk to the developing fetus. Similarly, levofloxacin can pass into breast milk and may harm the nursing infant. It is important to consult with a healthcare professional for alternative treatment options if you are pregnant or breastfeeding and require medication for an infection. They can evaluate the potential risks and benefits and guide you accordingly.

Precautions & Warnings

• Evo 500mg Tablet should not be taken if you have a known allergy or have had a severe reaction to any fluoroquinolone antibiotics. It is important to inform your doctor about any history of kidney, heart, or lung transplant, kidney disease, joint or tendon disorder, seizures, epilepsy, or regular physical activity.
• Evo 500mg Tablet may increase the risk of tendinitis or tendon rupture, especially in certain populations. It should be used with caution in patients with myasthenia gravis as it can worsen muscle weakness and potentially lead to severe breathing difficulties.
• It is advised to avoid dairy products while taking Evo 500mg Tablet as they may interfere with the absorption of the medication. Additionally, exposure to sunlight should be minimized as Levofloxacin can increase the risk of phototoxicity or photosensitivity reactions.
• Patients with epilepsy and irregular heartbeat (QT prolongation) should inform their doctor before taking Evo 500mg Tablet. It is important to monitor renal, hepatic, and hematopoietic functions periodically during treatment.
• Evo 500mg Tablet is not recommended during pregnancy and lactation, as it can be excreted in breast milk and may pose a risk to the baby.

Storage Conditions

Keep below 30°C and away from light and moisture. Keep out of children's reach.